Conformational Changes in DNA upon Ligand Binding Monitored by Circular Dichroism
Abstract
:1. Introduction
2. Conformational Polymorphism of DNA and DNA-Drug Complexes Monitored by CD
2.1. DNA (B-form, A-form, Z-form and Quadruplexes)
2.2. Chromomycin A3(Chro)
2.3. Mithramycin (Mith)
2.4. Actinomycin D (ActD)
2.5. Polyamines
2.6. Neomycin
2.7. Cisplatin
2.8. The Effect of Polyamines on the Metal Derivative Complex of Aureolic Family Drug-DNA Complexes
3. Conclusion
Acknowledgments
References
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Drugs | Sequence Specificity | Target Sequence |
---|---|---|
Anticancer drug | ||
Chromomycin A3 | G/C-rich sequence | d(TTGGCCAA)2 |
G/C-rich sequence | d(TTGGCCAA)2 | |
Mithramycin | G/C-rich sequence | d(TTGGCCAA)2 |
Blenomycin | G/C-rich sequence | d(CCCCAGCTGGGG) |
Actinomycin D | CTG triplet repeat sequence | d[(CAG)4·(CTG)16] |
telomeric G-quadruplex | d[GGG(TTAGGG)3] | |
CC-1065 | AT-rich sequence | d(GAATT) |
Doxorubicin | telomeric G-quadruplex | d[GGG(TTAGGG)3] |
Sabarubicin | telomeric G-quadruplex | d[GGG(TTAGGG)3] |
Streptonigrin | little sequence specificity | d(GCATGC)2 |
cis-Platin | GC-rich sequence | poly(dG)·poly(dC) |
SN-6999 | AT-rich sequence | poly(dA)·poly(dT) |
SN-18071 | AT-rich sequence | poly(dA)·poly(dT) |
Rebeccam ycin | sequences containing GpT (ApC) and TpG (CpA) steps | d(TGTTACGTT)2 |
Antiviral drug | ||
Lamivudine | little sequence specificity | Calf thymus DNA |
Valacyclovir | little sequence specificity | Calf thymus DNA |
isatin-β-thiosemicarbazone | little sequence specificity | Calf thymus DNA |
Tartrazine | little sequence specificity | Calf thymus DNA |
bis-netropsin | AT-rich sequence | poly(dA)·poly(dT) |
Distamycin | AT-rich sequence | poly(dA)·poly(dT) |
SN-7167 | AT-rich sequence | d(CGCGAATTCGCG) 2 |
Berenil | AT-rich sequence | d(G4A4G4-[T4]*-C4T4C4-[T4]*-G4T4G4) |
Antimicrobial drug | ||
Neomycin | A-form nucleic acids | 16S A-site rRNA |
Neomycin dimer | AT-rich sequence | d[5′-A12-x-T12-3′] |
NHP | AT-rich sequence | poly(dA)·poly(dT) |
NM | DNA:RNA hybrids | poly(dA)·poly(rU) |
perylene-neomycin conjugate | G-quadruplex DNA | 5′-d[AG3(T2AG3)3] |
Mitomycin C | GC-rich sequence | poly(dG) · poly(dC) |
Phenanthrolin | little sequence specificity | Calf thymus DNA |
Nogalamycin | little sequence specificity | Calf thymus DNA |
Enrofloxacin | little sequence specificity | Calf thymus DNA |
Neocarzinostatin | sequence-specific bulged DNA | |
Others | ||
Polyamine | Major groove of GC-rich duplexes | poly(dG)·poly(dC) |
Minor groove of AT-rich duplexes | poly(dA)·poly(dT) | |
Pentamidine | AT-rich sequence | poly(dA)·poly(dT) |
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Chang, Y.-M.; Chen, C.K.-M.; Hou, M.-H. Conformational Changes in DNA upon Ligand Binding Monitored by Circular Dichroism. Int. J. Mol. Sci. 2012, 13, 3394-3413. https://doi.org/10.3390/ijms13033394
Chang Y-M, Chen CK-M, Hou M-H. Conformational Changes in DNA upon Ligand Binding Monitored by Circular Dichroism. International Journal of Molecular Sciences. 2012; 13(3):3394-3413. https://doi.org/10.3390/ijms13033394
Chicago/Turabian StyleChang, Yu-Ming, Cammy K.-M. Chen, and Ming-Hon Hou. 2012. "Conformational Changes in DNA upon Ligand Binding Monitored by Circular Dichroism" International Journal of Molecular Sciences 13, no. 3: 3394-3413. https://doi.org/10.3390/ijms13033394