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Article

Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid

by
Zhenting Du
1,2,*,
Changmei Si
1,
Youqiang Li
1,
Yin Wang
1 and
Jing Lu
1
1
College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China
2
Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Talimu University, Alaer, Xinjiang 843300, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2012, 13(4), 4696-4703; https://doi.org/10.3390/ijms13044696
Submission received: 20 February 2012 / Revised: 19 March 2012 / Accepted: 30 March 2012 / Published: 12 April 2012
(This article belongs to the Section Green Chemistry)
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Abstract

A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%–95% yield.
Keywords: silica sulfuric acid; 5-substituted 1H-tetrazoles; [3+2] cycloaddition silica sulfuric acid; 5-substituted 1H-tetrazoles; [3+2] cycloaddition
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MDPI and ACS Style

Du, Z.; Si, C.; Li, Y.; Wang, Y.; Lu, J. Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid. Int. J. Mol. Sci. 2012, 13, 4696-4703. https://doi.org/10.3390/ijms13044696

AMA Style

Du Z, Si C, Li Y, Wang Y, Lu J. Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid. International Journal of Molecular Sciences. 2012; 13(4):4696-4703. https://doi.org/10.3390/ijms13044696

Chicago/Turabian Style

Du, Zhenting, Changmei Si, Youqiang Li, Yin Wang, and Jing Lu. 2012. "Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid" International Journal of Molecular Sciences 13, no. 4: 4696-4703. https://doi.org/10.3390/ijms13044696

APA Style

Du, Z., Si, C., Li, Y., Wang, Y., & Lu, J. (2012). Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid. International Journal of Molecular Sciences, 13(4), 4696-4703. https://doi.org/10.3390/ijms13044696

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