Curcumin Enhances Cytotoxic Effects of Bortezomib in Human Multiple Myeloma H929 Cells: Potential Roles of NF-κB/JNK
Abstract
:1. Introduction
2. Results and Discussion
2.1. Curcumin and PS-341 Altered Expression and Distribution Profiles of NF-κB p65
2.2. Curcumin and PS-341 Stabilized IκB through JNK Mechanism
2.3. Blockage of JNK Restored H929 Cells Survival
3. Experimental Section
3.1. Reagents
3.2. Cell Culture
3.3. Fluorescent Immunocytochemistry of NF-κB p65
3.4. Assay of IκB, NF-κB p65 and JNK
3.5. Analysis of JNK in H929 Cell Apoptosis
3.6. Statistical Analysis
4. Conclusion
Acknowledgments
References
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Bai, Q.-X.; Zhang, X.-Y. Curcumin Enhances Cytotoxic Effects of Bortezomib in Human Multiple Myeloma H929 Cells: Potential Roles of NF-κB/JNK. Int. J. Mol. Sci. 2012, 13, 4831-4838. https://doi.org/10.3390/ijms13044831
Bai Q-X, Zhang X-Y. Curcumin Enhances Cytotoxic Effects of Bortezomib in Human Multiple Myeloma H929 Cells: Potential Roles of NF-κB/JNK. International Journal of Molecular Sciences. 2012; 13(4):4831-4838. https://doi.org/10.3390/ijms13044831
Chicago/Turabian StyleBai, Qing-Xian, and Xiao-Yan Zhang. 2012. "Curcumin Enhances Cytotoxic Effects of Bortezomib in Human Multiple Myeloma H929 Cells: Potential Roles of NF-κB/JNK" International Journal of Molecular Sciences 13, no. 4: 4831-4838. https://doi.org/10.3390/ijms13044831