Cell Signaling through Protein Kinase C Oxidation and Activation
Abstract
:1. Introduction
2. The Protein Kinase C Family
2.1. Activation of PKCs
2.2. PKC Receptors and Localization of Isoenzymes
3. Regulation of Protein Kinase C by Reactive Oxygen Species (ROS)
4. Effect of Mitochondrial ROS Generation on PKC Activity
5. PKC Phosphorylates Nox Subunits for ROS Generation
6. PKC-Induced ROS Generation
7. Conclusions
Acknowledgements
References
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PKC group | PKC isoform | Cell/tissue type | References |
---|---|---|---|
Classical | PKCα | Kidney | [81] |
PKCβ | Leukemic cells; Neutrophils; and Monocytes. | [46,82–85] | |
Novel | PKCδ | Monocytes; Neuroblastoma; Neutrophils; and Fibroblast. | [75,86–88] |
PKCɛ | Pulmonary artery smooth muscle; and Myocytes. | [89,90] | |
Atypical | PKCζ | Leukocytes; Neurons; Hippocampus of mice; and Alveolus. | [91–94] |
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Cosentino-Gomes, D.; Rocco-Machado, N.; Meyer-Fernandes, J.R. Cell Signaling through Protein Kinase C Oxidation and Activation. Int. J. Mol. Sci. 2012, 13, 10697-10721. https://doi.org/10.3390/ijms130910697
Cosentino-Gomes D, Rocco-Machado N, Meyer-Fernandes JR. Cell Signaling through Protein Kinase C Oxidation and Activation. International Journal of Molecular Sciences. 2012; 13(9):10697-10721. https://doi.org/10.3390/ijms130910697
Chicago/Turabian StyleCosentino-Gomes, Daniela, Nathália Rocco-Machado, and José Roberto Meyer-Fernandes. 2012. "Cell Signaling through Protein Kinase C Oxidation and Activation" International Journal of Molecular Sciences 13, no. 9: 10697-10721. https://doi.org/10.3390/ijms130910697