Ionizing Radiation-Induced Responses in Human Cells with Differing TP53 Status
Abstract
:1. Introduction
2. Activation and Temporal Regulation of the DNA Damage Response Post-Irradiation
2.1. The p53-MDM2 Interaction
2.2. The p53-WIP1 Interaction
2.3. Multiple Functions of p21
3. Influence of p53 Dynamics on Cell Fate Post-Irradiation
3.1. Mathematical Modeling of p53 Dynamics and Cell Fate Post-Irradiation
3.2. Evaluation of p53 Dynamics and Cell Fate in Human Solid Tumor-Derived p53 Wild-Type Cell Lines Post-Irradiation
4. Does p53 Signaling Positively or Negatively Regulate Apoptosis in Response to DNA Damage?
5. Unwanted Side Effects of SIPS
6. Responses Triggered by Moderate Doses of Ionizing Radiation in p53-Deficient Human Cells
6.1. LFS Fibroblasts
6.2. Solid Tumor-Derived Cell Lines
7. Conclusions
Acknowledgments
Appendix
Topics | References |
---|---|
DNA damage response | [2–4,7,11,12,14,57,70,157,158] |
p53 structure | [7,159] |
p53 regulation and signaling | [28,44,160,161] |
p53-mediated responses through interaction with other proteins | [27] |
MDM2/MDMX | [30,44,45,161–163] |
WIP1 | [33,42,161] |
Multiple functions of p21 in the DNA damage response | [7,156,164] |
Mechanisms of radiation toxicity | [11,12,14,70] |
p21-dependent SIPS post-irradiation | [7,12,57] |
p16-dependent SIPS post-irradiation | [131] |
p53-based cancer therapies | [7,148] |
Conflicts of Interest
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Mirzayans, R.; Andrais, B.; Scott, A.; Wang, Y.W.; Murray, D. Ionizing Radiation-Induced Responses in Human Cells with Differing TP53 Status. Int. J. Mol. Sci. 2013, 14, 22409-22435. https://doi.org/10.3390/ijms141122409
Mirzayans R, Andrais B, Scott A, Wang YW, Murray D. Ionizing Radiation-Induced Responses in Human Cells with Differing TP53 Status. International Journal of Molecular Sciences. 2013; 14(11):22409-22435. https://doi.org/10.3390/ijms141122409
Chicago/Turabian StyleMirzayans, Razmik, Bonnie Andrais, April Scott, Ying W. Wang, and David Murray. 2013. "Ionizing Radiation-Induced Responses in Human Cells with Differing TP53 Status" International Journal of Molecular Sciences 14, no. 11: 22409-22435. https://doi.org/10.3390/ijms141122409