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Volume 14
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Article

Materials Characterization of Feraheme/Ferumoxytol and Preliminary Evaluation of Its Potential for Magnetic Fluid Hyperthermia

by
John P. Bullivant
1,
Shan Zhao
1,
Brad J. Willenberg
1,
Bettina Kozissnik
2,3,
Christopher D. Batich
1,3 and
Jon Dobson
1,2,3,*
1
Department of Materials Science & Engineering, University of Florida, Gainesville, FL 32611-6400, USA
2
Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611-6131, USA
3
Institute for Cell Engineering and Regenerative Medicine, University of Florida, Gainesville, FL 32611-6131, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(9), 17501-17510; https://doi.org/10.3390/ijms140917501
Submission received: 26 June 2013 / Revised: 5 August 2013 / Accepted: 21 August 2013 / Published: 26 August 2013
(This article belongs to the Special Issue Magnetic Nanoparticles 2013)
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Abstract

Feraheme, is a recently FDA-cleared superparamagnetic iron oxide nanoparticle (SPION)-based MRI contrast agent that is also employed in the treatment of iron deficiency anemia. Feraheme nanoparticles have a hydrodynamic diameter of 30 nm and consist of iron oxide crystallites complexed with a low molecular weight, semi-synthetic carbohydrate. These features are attractive for other potential biomedical applications such as magnetic fluid hyperthermia (MFH), since the carboxylated polymer coating affords functionalization of the particle surface and the size allows for accumulation in highly vascularized tumors via the enhanced permeability and retention effect. This work presents morphological and magnetic characterization of Feraheme by transmission electron microscopy (TEM), Energy dispersive X-ray spectroscopy (EDX), and superconducting quantum interference device (SQUID) magnetometry. Additionally, the results of an initial evaluation of the suitability of Feraheme for MFH applications are described, and the data indicate the particles possess promising properties for this application.
Keywords: Feraheme; magnetic fluid hyperthermia; magnetic nanoparticles; MRI contrast Feraheme; magnetic fluid hyperthermia; magnetic nanoparticles; MRI contrast

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MDPI and ACS Style

Bullivant, J.P.; Zhao, S.; Willenberg, B.J.; Kozissnik, B.; Batich, C.D.; Dobson, J. Materials Characterization of Feraheme/Ferumoxytol and Preliminary Evaluation of Its Potential for Magnetic Fluid Hyperthermia. Int. J. Mol. Sci. 2013, 14, 17501-17510. https://doi.org/10.3390/ijms140917501

AMA Style

Bullivant JP, Zhao S, Willenberg BJ, Kozissnik B, Batich CD, Dobson J. Materials Characterization of Feraheme/Ferumoxytol and Preliminary Evaluation of Its Potential for Magnetic Fluid Hyperthermia. International Journal of Molecular Sciences. 2013; 14(9):17501-17510. https://doi.org/10.3390/ijms140917501

Chicago/Turabian Style

Bullivant, John P., Shan Zhao, Brad J. Willenberg, Bettina Kozissnik, Christopher D. Batich, and Jon Dobson. 2013. "Materials Characterization of Feraheme/Ferumoxytol and Preliminary Evaluation of Its Potential for Magnetic Fluid Hyperthermia" International Journal of Molecular Sciences 14, no. 9: 17501-17510. https://doi.org/10.3390/ijms140917501

APA Style

Bullivant, J. P., Zhao, S., Willenberg, B. J., Kozissnik, B., Batich, C. D., & Dobson, J. (2013). Materials Characterization of Feraheme/Ferumoxytol and Preliminary Evaluation of Its Potential for Magnetic Fluid Hyperthermia. International Journal of Molecular Sciences, 14(9), 17501-17510. https://doi.org/10.3390/ijms140917501

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