Processed Aloe vera Gel Ameliorates Cyclophosphamide-Induced Immunotoxicity
Abstract
:1. Introduction
2. Results
2.1. Molecular Size Distribution of PAG Polysaccharides
2.2. Effect of Orally Administered PAG on CP-Induced Lymphopenia and Erythropenia
2.3. Oral Administration of PAG Preserves the Cytokine-Producing Capability of Peyer’s Patch Cells in CP-Treated Mice
2.4. PAG Polysaccharides Activate Peyer’s Patch Cells to Produce Hematopoietic Cytokines
2.5. Cytokines Produced by Polysaccharide-Stimulated Peyer’s Patch Cells Promote Bone Marrow Cell Proliferation
2.6. Oral Administration of PAG Restores CP-Suppressed Immunoglobulin A (IgA) Secretion in the Intestine
3. Discussion
4. Experimental Section
4.1. Preparation and Molecular Weight Determination of PAG
4.2. Animals, Immunosuppression, and Treatment Protocol
4.3. Blood Analysis
4.4. Peyer’s Patch Cell Preparation and Culture
4.5. Cytokine Production and Measurement
4.6. Measurement of IgA Content in the Feces
4.7. Statistical Analysis
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Im, S.-A.; Kim, K.-H.; Kim, H.-S.; Lee, K.-H.; Shin, E.; Do, S.-G.; Jo, T.H.; Park, Y.I.; Lee, C.-K. Processed Aloe vera Gel Ameliorates Cyclophosphamide-Induced Immunotoxicity. Int. J. Mol. Sci. 2014, 15, 19342-19354. https://doi.org/10.3390/ijms151119342
Im S-A, Kim K-H, Kim H-S, Lee K-H, Shin E, Do S-G, Jo TH, Park YI, Lee C-K. Processed Aloe vera Gel Ameliorates Cyclophosphamide-Induced Immunotoxicity. International Journal of Molecular Sciences. 2014; 15(11):19342-19354. https://doi.org/10.3390/ijms151119342
Chicago/Turabian StyleIm, Sun-A, Ki-Hyang Kim, Hee-Suk Kim, Ki-Hwa Lee, Eunju Shin, Seon-Gil Do, Tae Hyung Jo, Young In Park, and Chong-Kil Lee. 2014. "Processed Aloe vera Gel Ameliorates Cyclophosphamide-Induced Immunotoxicity" International Journal of Molecular Sciences 15, no. 11: 19342-19354. https://doi.org/10.3390/ijms151119342