Dexamethasone Improves Heat Stroke-Induced Multiorgan Dysfunction and Damage in Rats
Abstract
:1. Introduction
2. Results and Discussion
2.1. DXM Improves Survival during Heat Stroke in a Dose-Dependent Manner
Treatment Groups | Survival Time (min) |
---|---|
1. Normal saline-treated (1 mL/kg, iv) normothermic control rats | >480 |
2. Normal saline-treated (1 mL/kg, iv) heat stroke rats | 24 ± 3 †,‡ |
3. Dexamethasone (4 mg/kg, iv)-treated heat stroke rats | 104 ± 9 *,‡ |
4. Dexamethasone (6 mg/kg, iv)-treated heat stroke rats | 204 ± 25 *,† |
5. Dexamethasone (8 mg/kg, iv)-treated heat stroke rats | 268 ± 27 *,†,‡ |
2.2. DXM Ameliorates Arterial Hypotension, Cerebral Ischemia and Damage during Heat Stroke
2.3. DXM Attenuates Heat Stroke-Induced Hypercoagulable State
2.4. DXM Protects from Hepatic and Renal Dysfunction during Heat Stroke
2.5. DXM Reduces both IL-1β and Tumor Necrosis Factor-α (TNF-α) Increase but Enhances Interleukin-10 (IL-10) during Heat Stroke
2.6. Discussion
3. Materials and Methods
3.1. Experimental Animals
3.2. Surgery and Physiological Parameter Monitoring
3.3. Induction of Heat Stroke and Experimental Design
3.4. Measurement of CBF
3.5. Measurements of Extracellular Ischemia and Damage Markers in Brain
3.6. Biochemical Measurements
3.7. Measurement for Serum Cytokines
3.8. Data Analysis
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Liu, C.-C.; Shih, M.-F.; Wen, Y.-S.; Lai, Y.-H.; Yang, T.-H. Dexamethasone Improves Heat Stroke-Induced Multiorgan Dysfunction and Damage in Rats. Int. J. Mol. Sci. 2014, 15, 21299-21313. https://doi.org/10.3390/ijms151121299
Liu C-C, Shih M-F, Wen Y-S, Lai Y-H, Yang T-H. Dexamethasone Improves Heat Stroke-Induced Multiorgan Dysfunction and Damage in Rats. International Journal of Molecular Sciences. 2014; 15(11):21299-21313. https://doi.org/10.3390/ijms151121299
Chicago/Turabian StyleLiu, Chia-Chyuan, Mei-Fen Shih, Yi-Szu Wen, Ying-Hsiu Lai, and Tsai-Hsiu Yang. 2014. "Dexamethasone Improves Heat Stroke-Induced Multiorgan Dysfunction and Damage in Rats" International Journal of Molecular Sciences 15, no. 11: 21299-21313. https://doi.org/10.3390/ijms151121299