The Estrogen Receptor-β Expression in De Quervain’s Disease
Abstract
:1. Introduction
2. Results
2.1. The Expression of Estrogen Receptor (ER)-β Was Associated with the Severity of De Quervain’s Disease
Patient Number | Age at Surgery (Years) | Gender | Side | Duration (Months) | Corticosteroid Injection | Age at Menopause (Years) | Grade I | Grade II | Grade III |
---|---|---|---|---|---|---|---|---|---|
1 | 61 | F | L | 4 | No | 50 | No | Yes | Yes |
2 | 53 | F | L | 7 | No | 53 | No | Yes | Yes |
3 | 64 | F | L | 3 | No | 53 | No | Yes | No |
4 | 50 | F | L | 5 | No | No | No | Yes | Yes |
5 | 38 | M | R | 6 | 1 | No | Yes | Yes | Yes |
6 | 73 | F | R | 16 | 1 | 56 | Yes | Yes | Yes |
7 | 51 | F | R | 4 | No | 49 | Yes | Yes | No |
8 | 68 | F | R | 3 | No | 51 | No | Yes | No |
9 | 54 | F | R | 5 | No | 49 | Yes | Yes | No |
10 | 53 | M | R | 7 | No | No | Yes | Yes | No |
11 | 54 | F | L | 12 | 1 | 52 | Yes | Yes | No |
12 | 44 | F | L | 18 | No | No | No | Yes | Yes |
13 | 52 | F | L | 3 | No | 50 | No | Yes | Yes |
14 | 53 | F | L | 8 | No | 53 | No | Yes | No |
15 | 57 | F | L | 14 | 1 | 50 | No | Yes | Yes |
16 | 65 | F | L | 12 | No | 50 | No | Yes | Yes |
2.2. The Age Was Related to the Degree of ER-β Expression and Disease Severity
2.3. Inflammation and Angiogenesis Occurred and Increased along with Disease Progression
Factors | Grade I | Grade II | Grade III |
---|---|---|---|
IL-1β | 13.08% ± 5.75% | 67.65% ± 16.17% *** | 89.43% ± 8.53% *** |
IL-6 | 12.29% ± 8.72% | 67.23% ± 17.63% *** | 84.16% ± 10.41% *** |
COX-2 | 8.81% ± 6.87% | 92.69% ± 5.51% *** | 87.07% ± 7.64% *** |
VEGF | 12.33% ± 4.60% | 75.78% ± 17.70% *** | 90.63% ± 4.45% *** |
vWF | 5.96% ± 0.10% | 48.99% ± 23.15% | 70.21% ± 15.54% * |
3. Discussion
4. Experimental Section
4.1. The Disease Diagnosis
4.2. Tissue Collection and Section Evaluation
4.3. Immunohistochemical Staining
4.4. Cell Counting
4.5. Statistical Analysis
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Shen, P.-C.; Wang, P.-H.; Wu, P.-T.; Wu, K.-C.; Hsieh, J.-L.; Jou, I.-M. The Estrogen Receptor-β Expression in De Quervain’s Disease. Int. J. Mol. Sci. 2015, 16, 26452-26462. https://doi.org/10.3390/ijms161125968
Shen P-C, Wang P-H, Wu P-T, Wu K-C, Hsieh J-L, Jou I-M. The Estrogen Receptor-β Expression in De Quervain’s Disease. International Journal of Molecular Sciences. 2015; 16(11):26452-26462. https://doi.org/10.3390/ijms161125968
Chicago/Turabian StyleShen, Po-Chuan, Ping-Hui Wang, Po-Ting Wu, Kuo-Chen Wu, Jeng-Long Hsieh, and I-Ming Jou. 2015. "The Estrogen Receptor-β Expression in De Quervain’s Disease" International Journal of Molecular Sciences 16, no. 11: 26452-26462. https://doi.org/10.3390/ijms161125968