Synthesis and Evaluation of Neuroprotective Selenoflavanones
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis of the Selenoflavanones and Flavanones
2.2. Physicochemical Properties of the Selenoflavanones and Flavanones
Selenoflavanone | Physicochemical Properties | Flavanone | Physicochemical Properties | ||
---|---|---|---|---|---|
tPSA a (Å2) | ClogP a | tPSA a (Å2) | ClogP a | ||
1a | 26.3 | 4.20 | 2a | 35.5 | 3.50 |
1b | 35.5 | 3.88 | 2b | 44.8 | 3.11 |
2.3. Biological Activities of the Selenoflavanones and Flavanones
2.3.1. Antioxidant Effect and Cytotoxicity of the Selenoflavanones and Flavanones
2.3.2. Neuroprotective Activity of the Selenoflavanones and Flavanones
3. Experimental Section
3.1. Chemistry
3.1.1. General Information
3.1.2. General Procedure for the Acylation of Bromobenzenes
3.1.3. General Procedure for the Formation of Selenoflavanones
3.1.4. General Procedure for the Acylation of Phenols
3.1.5. General Procedure for the Formation of Flavanones
3.2. In Vitro Cell Viability
3.2.1. Cell Culture
3.2.2. MTT Assay
3.3. In Vivo Neuroprotective Activity
3.3.1. Transient Ischemia Model
3.3.2. Drug Administration
3.3.3. Morphometric Measurement of Infarct Volume and Edema
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Choi, Y.-S.; Kim, D.-M.; Kim, Y.-J.; Yang, S.; Lee, K.-T.; Ryu, J.H.; Jeong, J.-H. Synthesis and Evaluation of Neuroprotective Selenoflavanones. Int. J. Mol. Sci. 2015, 16, 29574-29582. https://doi.org/10.3390/ijms161226188
Choi Y-S, Kim D-M, Kim Y-J, Yang S, Lee K-T, Ryu JH, Jeong J-H. Synthesis and Evaluation of Neuroprotective Selenoflavanones. International Journal of Molecular Sciences. 2015; 16(12):29574-29582. https://doi.org/10.3390/ijms161226188
Chicago/Turabian StyleChoi, Yong-Sung, Dong-Myung Kim, Yoon-Jung Kim, Sai Yang, Kyung-Tae Lee, Jong Hoon Ryu, and Jin-Hyun Jeong. 2015. "Synthesis and Evaluation of Neuroprotective Selenoflavanones" International Journal of Molecular Sciences 16, no. 12: 29574-29582. https://doi.org/10.3390/ijms161226188