A Variant in the Osteoprotegerin Gene Is Associated with Coronary Atherosclerosis in Patients with Rheumatoid Arthritis: Results from a Candidate Gene Study
Abstract
:1. Introduction
2. Results
Patient Characteristics | With Coronary Calcium (n = 70) | Without Coronary Calcium (n = 70) | p-Value |
---|---|---|---|
Age (years) | 60 ± 9 | 48 ± 10 | <0.001 |
Female sex (%) | 59% | 80% | 0.01 |
Caucasian | 90% | 87% | 0.40 |
Disease duration (years) | 11 ± 11 | 6 ± 8 | 0.03 |
Systolic blood pressure | 138 ± 21 | 129 ± 17 | 0.02 |
Diastolic blood pressure | 76 ± 11 | 75 ± 10 | 0.24 |
Body mass index | 29 ± 6 | 30 ± 7 | 0.64 |
Total cholesterol | 184 ± 38 | 184 ± 41 | 0.67 |
LDL cholesterol | 113 ± 27 | 109 ± 32 | 0.42 |
SNP | Gene | Major, Minor Allele | Minor Allele Frequency | Odds Ratio * (95% C.I.) | p-Value |
---|---|---|---|---|---|
rs2073618 ** | TNFRSF11B | G,C | 0.36 | 4.09 (1.93–8.70) | 0.00026 |
rs522616 | MMP3 | T,C | 0.29 | 4.43 (1.77–11.10) | 0.001 |
rs2853694 | IL12B | T,C | 0.29 | 3.09 (1.53–6.24) | 0.002 |
rs3918249 | MMP9 | T,C | 0.49 | 0.36 (0.18–0.69) | 0.002 |
rs17576 | MMP9 | A,G | 0.45 | 0.34 (0.17–0.68) | 0.002 |
rs3918253 | MMP9 | C,T | 0.28 | 0.38 (0.20–0.72) | 0.003 |
rs2274756 | MMP9 | G,A | 0.16 | 0.24 (0.09–0.64) | 0.004 |
rs751271 | NOD2 | T,G | 0.49 | 2.57 (1.33–4.96) | 0.005 |
rs650108 | MMP3 | G,A | 0.41 | 2.82 (1.29–6.17) | 0.009 |
rs1800947 | CRP | C,G | 0.04 | 5.93 (1.43–24.71) | 0.014 |
rs9562414 | TNFSF11 | A,G | 0.06 | 0.25 (0.08–0.79) | 0.019 |
rs2107545 | MPO | T,C | 0.26 | 0.42 (0.20–0.89) | 0.023 |
rs3745367 | RETN | G,A | 0.39 | 0.45 (0.22–0.91) | 0.026 |
rs10954213 | IRF5 | G,A | 0.47 | 0.50 (0.27–0.94) | 0.030 |
rs633137 | TNFSF11 | T,A | 0.08 | 0.34 (0.13–0.91) | 0.031 |
rs2243828 | MPO | A,G | 0.23 | 0.43 (0.20–0.96) | 0.040 |
rs1801274 | FCGR2A | A,G | 0.43 | 0.52 (0.28–1.00) | 0.049 |
3. Discussion
4. Methods
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Chung, C.P.; Solus, J.F.; Oeser, A.; Li, C.; Raggi, P.; Smith, J.R.; Stein, C.M. A Variant in the Osteoprotegerin Gene Is Associated with Coronary Atherosclerosis in Patients with Rheumatoid Arthritis: Results from a Candidate Gene Study. Int. J. Mol. Sci. 2015, 16, 3885-3894. https://doi.org/10.3390/ijms16023885
Chung CP, Solus JF, Oeser A, Li C, Raggi P, Smith JR, Stein CM. A Variant in the Osteoprotegerin Gene Is Associated with Coronary Atherosclerosis in Patients with Rheumatoid Arthritis: Results from a Candidate Gene Study. International Journal of Molecular Sciences. 2015; 16(2):3885-3894. https://doi.org/10.3390/ijms16023885
Chicago/Turabian StyleChung, Cecilia P., Joseph F. Solus, Annette Oeser, Chun Li, Paolo Raggi, Jeffrey R. Smith, and C. Michael Stein. 2015. "A Variant in the Osteoprotegerin Gene Is Associated with Coronary Atherosclerosis in Patients with Rheumatoid Arthritis: Results from a Candidate Gene Study" International Journal of Molecular Sciences 16, no. 2: 3885-3894. https://doi.org/10.3390/ijms16023885