Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism
Abstract
:1. Introduction
2. Uptake and Metabolism of Vitamin A (VA)
3. Characteristics of a Retinoic Acid Response Element (RARE)
Type | Gene | RARE Sequences | References |
---|---|---|---|
DR0 | Socs3 | AGTTCA AGGTCA | Moutier et al. [48] |
Msi2 | GGGTCA AGGTCA | ||
DR1 | Crbp2 | AGGTCA c AGTTCA | Bastien et al. [55] |
Crabp2 | TGACCT c TGCCCT | Durand et al. [56] | |
DR2 | Gck | TGACCT tg TGACAC | Li et al. [54] |
Epo | GGGTCA ag AGGTCA | Brade et al. [57] | |
DR5 | Cyp26a1 | AGTTCA cccaa AGTTCA | Loudig et al. [58] |
Rarb2 | GTTCAC cgaaa GTTCAC | Sucov et al. [43] | |
Simple DR8 | Rqcd1 | GGGTCA gaggtgag AGGTCA | Moutier et al. [48] |
Dedd | AGGTCA cgatctgg AGTTCA | ||
Composite DR8 | Mafa | AGGTCA ga AGTTCA AGGTCA | |
Nrp1 | GGATCA aa AGTTCA AGGTCA | ||
IR0 | Trim16 | GGGTCA TGACCC | |
Tr2-11 | GGGTCA CGAACT | Lee and Wei [59] |
4. Nuclear Receptors (NRs) Mediating Retinoic Acid (RA) Effects
4.1. Introduction of Nuclear Receptors (NRs)
4.2. RARs Are Primary Mediators of RA Signaling
4.3. The Role of RXRs in RA Signaling
4.4. HNF4α and Its Potential Association with RA Signaling Pathway
4.5. The Role of COUP-TFII in RA Signaling
4.6. The Role of PPARβ/δ in RA Signaling
4.7. Promiscuous Binding of RARs, RXRs, HNF4, and COUP-TFII to RAREs
5. Conclusions and Future Perspectives
Acknowledgments
Author Contributions
Conflicts of Interests
References
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Zhang, R.; Wang, Y.; Li, R.; Chen, G. Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism. Int. J. Mol. Sci. 2015, 16, 14210-14244. https://doi.org/10.3390/ijms160614210
Zhang R, Wang Y, Li R, Chen G. Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism. International Journal of Molecular Sciences. 2015; 16(6):14210-14244. https://doi.org/10.3390/ijms160614210
Chicago/Turabian StyleZhang, Rui, Yueqiao Wang, Rui Li, and Guoxun Chen. 2015. "Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism" International Journal of Molecular Sciences 16, no. 6: 14210-14244. https://doi.org/10.3390/ijms160614210