Neurological and Epigenetic Implications of Nutritional Deficiencies on Psychopathology: Conceptualization and Review of Evidence
Abstract
:1. Introduction
2. Overview of the Framework
3. Macro- and Micro-Nutrient Deficiency Are Risk Factors for Psychopathology
3.1. Macro-Nutrition Deficiency and Psychopathology
3.2. Micro-Nutrition Deficiency and Psychopathology
4. Mechanisms Mediating Nutrition Deficiency and Psychopathology: Epigenetics and Altered Brain Structure and Function
4.1. Nutrient Deficiency Alters Epigenetic Processes, Particularly in Early Development
4.1.1. Influence of Nutrition on DNA Methylation, Histone Modification, and Gene Expression
4.1.2. Influence of Epigenetic Changes on Brain Dysfunction and Psychopathology
4.2. Altered Brain Structure and Function as a Mediator
4.2.1. Impaired Brain Development
4.2.2. Signaling Molecule Imbalance
4.2.3. Increasing Neurotoxicity
5. Conclusions
Acknowledgments
Conflicts of Interest
References
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Liu, J.; Zhao, S.R.; Reyes, T. Neurological and Epigenetic Implications of Nutritional Deficiencies on Psychopathology: Conceptualization and Review of Evidence. Int. J. Mol. Sci. 2015, 16, 18129-18148. https://doi.org/10.3390/ijms160818129
Liu J, Zhao SR, Reyes T. Neurological and Epigenetic Implications of Nutritional Deficiencies on Psychopathology: Conceptualization and Review of Evidence. International Journal of Molecular Sciences. 2015; 16(8):18129-18148. https://doi.org/10.3390/ijms160818129
Chicago/Turabian StyleLiu, Jianghong, Sophie R. Zhao, and Teresa Reyes. 2015. "Neurological and Epigenetic Implications of Nutritional Deficiencies on Psychopathology: Conceptualization and Review of Evidence" International Journal of Molecular Sciences 16, no. 8: 18129-18148. https://doi.org/10.3390/ijms160818129