Effect of Lead (Pb) on Inflammatory Processes in the Brain
Abstract
:1. Introduction
2. Effects of Lead on the Expression of Cytokines in Brain
2.1. Expression of Interleukin 6 and TGF-β1
2.1.1. The Mechanism of the Effect of Pb on the Gene Expression of IL-6 and TGF-β1
2.1.2. Effect of Pb on IL-6 and TGF-β1 Signal Transduction Pathways
2.2. Effect of Pb on Interleukin 16 Expression
2.3. Effect of Pb on Interleukin 18 Expression
2.4. Effect of Pb on Interleukin 10 Expression
3. Effects of Pb on Enzymes
3.1. Effects of Pb on the Gene Expression and Activity of Cyclooxygenase-2 (COX 2)
3.2. Effect of Pb on the Gene Expression and Activity of Caspase-1 and NOS 2
3.3. Effects of Pb on the Expression of Proteases
4. Effects of Pb on Microglia and Astroglia
5. Effects of Pb on the Expression of P2X4 and P2X7
6. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Chibowska, K.; Baranowska-Bosiacka, I.; Falkowska, A.; Gutowska, I.; Goschorska, M.; Chlubek, D. Effect of Lead (Pb) on Inflammatory Processes in the Brain. Int. J. Mol. Sci. 2016, 17, 2140. https://doi.org/10.3390/ijms17122140
Chibowska K, Baranowska-Bosiacka I, Falkowska A, Gutowska I, Goschorska M, Chlubek D. Effect of Lead (Pb) on Inflammatory Processes in the Brain. International Journal of Molecular Sciences. 2016; 17(12):2140. https://doi.org/10.3390/ijms17122140
Chicago/Turabian StyleChibowska, Karina, Irena Baranowska-Bosiacka, Anna Falkowska, Izabela Gutowska, Marta Goschorska, and Dariusz Chlubek. 2016. "Effect of Lead (Pb) on Inflammatory Processes in the Brain" International Journal of Molecular Sciences 17, no. 12: 2140. https://doi.org/10.3390/ijms17122140