Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury
Abstract
:1. Introduction
2. Results
2.1. Functional Deletion of TLR4 Confers Acute Protection in a Model of Ischemic AKI
2.2. Functional Deletion of TLR4 Did Not Significantly Alter the Early Inflammatory Response in a Mouse Model of Ischemic AKI
2.3. Functional Deletion of TLR4 Preserved Microvascular Density Following an Episode of Ischemic AKI
2.4. Functional Deletion of TLR4 Did Not Significantly Alter the Development of Fibrosis Following an Episode of Ischemic AKI
3. Discussion
4. Experimental Section
4.1. Animals and Experimental Models
4.2. Histopathology and Microscopy
4.3. Statistical Analysis
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Dagher, P.C.; Hato, T.; Mang, H.E.; Plotkin, Z.; Richardson, Q.V.; Massad, M.; Mai, E.; Kuehl, S.E.; Graham, P.; Kumar, R.; et al. Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury. Int. J. Mol. Sci. 2016, 17, 647. https://doi.org/10.3390/ijms17050647
Dagher PC, Hato T, Mang HE, Plotkin Z, Richardson QV, Massad M, Mai E, Kuehl SE, Graham P, Kumar R, et al. Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury. International Journal of Molecular Sciences. 2016; 17(5):647. https://doi.org/10.3390/ijms17050647
Chicago/Turabian StyleDagher, Pierre C., Takashi Hato, Henry E. Mang, Zoya Plotkin, Quentin V. Richardson, Michael Massad, Erik Mai, Sarah E. Kuehl, Paige Graham, Rakesh Kumar, and et al. 2016. "Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury" International Journal of Molecular Sciences 17, no. 5: 647. https://doi.org/10.3390/ijms17050647