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Review

Interaction between Mesenchymal Stem Cells and B-Cells

by
Linxiao Fan
†,
Chenxia Hu
†,
Jiajia Chen
,
Panpan Cen
,
Jie Wang
and
Lanjuan Li
*
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2016, 17(5), 650; https://doi.org/10.3390/ijms17050650
Submission received: 25 February 2016 / Revised: 19 April 2016 / Accepted: 19 April 2016 / Published: 5 May 2016
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Abstract

Mesenchymal stem cells (MSCs) are multipotent; non-hematopoietic stem cells. Because of their immunoregulatory abilities; MSCs are widely used for different clinical applications. Compared with that of other immune cells; the investigation of how MSCs specifically regulate B-cells has been superficial and insufficient. In addition; the few experimental studies on this regulation are often contradictory. In this review; we summarize the various interactions between different types or states of MSCs and B-cells; address how different types of MSCs and B-cells affect this interaction and examine how other immune cells influence the regulation of B-cells by MSCs. Finally; we hypothesize why there are conflicting results on the interaction between MSCs and B-cells in the literature.
Keywords: mesenchymal stem cell; B-cell; immune regulation; immune suppression; systemic lupus erythematous; graft-versus-host disease; T-cell; plasma cell; cytokine mesenchymal stem cell; B-cell; immune regulation; immune suppression; systemic lupus erythematous; graft-versus-host disease; T-cell; plasma cell; cytokine
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MDPI and ACS Style

Fan, L.; Hu, C.; Chen, J.; Cen, P.; Wang, J.; Li, L. Interaction between Mesenchymal Stem Cells and B-Cells. Int. J. Mol. Sci. 2016, 17, 650. https://doi.org/10.3390/ijms17050650

AMA Style

Fan L, Hu C, Chen J, Cen P, Wang J, Li L. Interaction between Mesenchymal Stem Cells and B-Cells. International Journal of Molecular Sciences. 2016; 17(5):650. https://doi.org/10.3390/ijms17050650

Chicago/Turabian Style

Fan, Linxiao, Chenxia Hu, Jiajia Chen, Panpan Cen, Jie Wang, and Lanjuan Li. 2016. "Interaction between Mesenchymal Stem Cells and B-Cells" International Journal of Molecular Sciences 17, no. 5: 650. https://doi.org/10.3390/ijms17050650

APA Style

Fan, L., Hu, C., Chen, J., Cen, P., Wang, J., & Li, L. (2016). Interaction between Mesenchymal Stem Cells and B-Cells. International Journal of Molecular Sciences, 17(5), 650. https://doi.org/10.3390/ijms17050650

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