Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract
Abstract
:1. Introduction
2. Inflammation and Cancer
3. H. pylori-Related Gastric Disease
4. Intestinal Diseases
5. Discussion and Conclusions
Acknowledgments
Conflicts of Interest
Abbreviations
AJC | apical junction complex |
CRC | colorectal cancer |
CD | Crohn’s disease |
GC | gastric cancer |
GGT | γ-glutamyl transpeptidase |
IBD | inflammatory bowel disease |
IMFs | intestinal fibroblasts and myofibroblasts |
MMR | mismatch repair |
MSI | microsatellite instability |
MyD88 | myeloid differentiation primary-response gene 88 |
poly IC | polyriboinosinic-polyribocytidylic acid |
RISC | RNA-induced silencing complex |
SOCS1 | suppressor of cytokine signaling 1 |
T4SS | type IV secretion system |
TLR/IL-1 | Toll-like receptor/interleukin-1 |
TP53INP | tumor protein p53-inducible nuclear protein 1 |
UC | ulcerative colitis |
VacA | vacuolating toxin A |
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Disease | Expression | Function | Target(s) |
---|---|---|---|
H. pylori-related gastric disease | |||
H. pylori infection | Up-regulation | Decreases the survival of intracellular H. Pylori [49], induces the expression of TNF-α [50], enhances the macrophage resistance to apoptosis [46], or reduces the release of proinflammatory cytokines and signal transduction [11]. | Tspan14, Lpin1, and Pmaip1 [46] |
Peptic ulcers | Up-regulation | Decreases the over-expression of IL-6 and impairs the immune response to H. pylori (cagA+) [41]. | |
Gastric MALT lymphomas | Up-regulation | Induces cell cycle arrest and apoptosis [43]. | TP53INP [43] |
GC | Down-regulation | Accelerates cell growth and invasion in human gastric carcinoma cells [59], inhibit GC cell metastasis [61]. | c-myc [59], Smad2 [61] |
Intestinal diseases | |||
IBD | Up-regulation | Activates the NF-κB signaling pathway and up-regulate inflammatory cytokines such as IL-8 [76], modulates the inflammatory phenotype of IMFs [79], Loss of miR-155 protects mice from experimental colitis by decreasing TNF-(IL-6, IL-12, IL-17, and IFN-γ production [81]. | FOXO3a [76], SOCS1 [79] |
CRC | Up-regulation | Promotes proliferation, invasion, and metastasis of CRC cells, is closely related to tumor location, tumor grade, TNM staging, and distant metastasis in CRC [12], induces MSI by regulating the MMR system [85]. |
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Wan, J.; Xia, L.; Xu, W.; Lu, N. Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract. Int. J. Mol. Sci. 2016, 17, 709. https://doi.org/10.3390/ijms17050709
Wan J, Xia L, Xu W, Lu N. Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract. International Journal of Molecular Sciences. 2016; 17(5):709. https://doi.org/10.3390/ijms17050709
Chicago/Turabian StyleWan, Jianhua, Liang Xia, Wenting Xu, and Nonghua Lu. 2016. "Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract" International Journal of Molecular Sciences 17, no. 5: 709. https://doi.org/10.3390/ijms17050709