Liver Fat Measured by MR Spectroscopy: Estimate of Imprecision and Relationship with Serum Glycerol, Caeruloplasmin and Non-Esterified Fatty Acids
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Subjects
4.2. Laboratory Methods
4.3. Estimation of Liver Fat
4.4. Statistical Methods
5. Main Messages
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Measurement | Tau | p Value |
---|---|---|
BMI kg·m−2 | 0.59 | 0.012 |
NEFA umol·L−1 | −0.22 | 0.3 |
Glycerol umol·L−1 | −0.59 | 0.014 |
Glucose mmol·L−1 | 0.13 | 0.5 |
Insulin mU·L−1 | 0.48 | 0.042 |
HOMA-S% | −0.48 | 0.042 |
HOMA-B% | 0.48 | 0.042 |
Triglyceride mmol·L−1 | 0.37 | 0.1 |
Caeruloplasmin g·L−1 | −0.55 | 0.047 |
Iron umol·L−1 | 0.15 | 0.5 |
TIBC umol·L−1 | 0.24 | 0.3 |
Iron % saturation of TIBC | 0.31 | 0.2 |
Ferritin µg·L−1 | 0.4 | 0.1 |
Alcohol units/week | −0.17 | 0.5 |
A1AT g·L−1 | −0.22 | 0.3 |
Population Characteristics | Median (Range) | Reference Range |
---|---|---|
Gender (n = 11) | 10 males/1 female | - |
Age | 51 (32–67) | - |
BMI kg·m−2 | 29.6 (20.2–40.4) | <25% * |
Alcohol (units) | 3 (Male) | 0–24 |
5 (Female) | 0–14 | |
TC mmol·L−1 | 5.7 (4.6–8.5) | <4.0 * |
HDL mmol·L−1 | Female 1.26 | Female > 1.2 * |
Male 1.34 (0.2–1.49) | Male > 1.0 * | |
TG mmol·L−1 | 2.7 (0.6–6.0) | <1.7 * |
NEFA umol·L−1 | 302 (138–491) | 130–1050 |
Glycerol umol·L−1 | 90 (10–210) | 27–137 |
Insulin mU·L−1 | 17.2 (8.3–87.4) | 3.4–6.4 ** |
Glucose mmol·L−1 | 5.6 (5.0–7.5) | <6.1 |
HOMA-S% | 43.9 (13.3–91.9) | 100% |
HOMA-B% | 126.4 (92.6–254.5) | 100% |
Liver fat g·kg−1 water | 44.0 (10.0–332.0) | <5.6 (95th centile) |
ALT U·L−1 | 56 (19–119) | 5–40 |
Iron umol·L−1 | 20.2 (10.2–28.1) | 7–29 |
TIBC umol·L−1 | 65 (50–74) | 45–70 |
Iron % of TIBC | 33 (17.6–49.4) | <50% *** |
Ferritin µg·L−1 | 187 (41.4–549.7) | 15–200 |
Caeruloplasmin g·L−1 | 0.31 (0.2–0.39) | 0.25–0.63 |
A1AT g·L−1 | 1.32 (1.07–1.95) | 1.0–2.0 |
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France, M.; Kwok, S.; Soran, H.; Williams, S.; Ho, J.H.; Adam, S.; Canoy, D.; Liu, Y.; Durrington, P.N. Liver Fat Measured by MR Spectroscopy: Estimate of Imprecision and Relationship with Serum Glycerol, Caeruloplasmin and Non-Esterified Fatty Acids. Int. J. Mol. Sci. 2016, 17, 1089. https://doi.org/10.3390/ijms17071089
France M, Kwok S, Soran H, Williams S, Ho JH, Adam S, Canoy D, Liu Y, Durrington PN. Liver Fat Measured by MR Spectroscopy: Estimate of Imprecision and Relationship with Serum Glycerol, Caeruloplasmin and Non-Esterified Fatty Acids. International Journal of Molecular Sciences. 2016; 17(7):1089. https://doi.org/10.3390/ijms17071089
Chicago/Turabian StyleFrance, Michael, See Kwok, Handrean Soran, Steve Williams, Jan Hoong Ho, Safwaan Adam, Dexter Canoy, Yifen Liu, and Paul N. Durrington. 2016. "Liver Fat Measured by MR Spectroscopy: Estimate of Imprecision and Relationship with Serum Glycerol, Caeruloplasmin and Non-Esterified Fatty Acids" International Journal of Molecular Sciences 17, no. 7: 1089. https://doi.org/10.3390/ijms17071089