Circulating MicroRNAs: A Next-Generation Clinical Biomarker for Digestive System Cancers
Abstract
:1. Introduction
2. The Biology and Detection of Circulating miRNAs
3. Circulating miRNAs as Cancer Diagnostic Tools
3.1. Esophageal Cancer
3.2. Gastric Cancer
3.3. Colorectal Cancer
3.4. Hepatocellular Cancer
3.5. Pancreatic Cancer
4. Malignant Potential, Tumor Recurrence, and Prognostic Biomarkers
4.1. Esophageal Cancer (ECa)
4.2. Gastric Cancer (GC)
4.3. Colorectal Cancer (CRC)
4.4. Hepatocellular Carcinoma (HCC)
4.5. Pancreatic Cancer (PCa)
5. Predicting Tool for Tumor Chemosensitivity
6. Conclusions
Acknowledgments
Conflicts of Interest
References
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Cancer Type | Expression Level 1 | Cancer Diagnostic Tools | Malignant Potential, Tumor Recurrence, And Prognostic Biomarker | Predicting Tool For Chemosensitivity | References |
---|---|---|---|---|---|
Esophegeal cancer | High | miR-10a, miR-22, miR-100, miR-127, miR-133a, miR-148b, miR-223, miR-21, miR-155, miR-18a, miR-1246, miR-16, miR-25, miR-320a, let-7e, miR-15b | miR-21, miR-16, miR-1246, miR-192, miR-222, miR-3935, miR-4286 | miR-200c, miR-27a/b, miR-21 | [13,14,15,16,17,18,19,20,74,75,76,77,87,88,89] |
Low | miR-375, miR-718, miR-30a/miR-324, miR-17/miR-194 | miR-375, miR-302c | - | ||
Gastric cancer | High | miR-17-5p, miR-21, miR-106a/b, miR-18a, miR-378, miR-451, miR-486, miR-21, miR-200c, miR-421, miR-199a, miR-122, miR-192, miR-222, miR-16, miR-25, miR-92a, miR-940, miR-223, miR-19b, miR-194 | miR-200c, miR-21, miR-222, miR-18a | - | [21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,78,79] |
Low | miR-141, miR-1233 | miR-203 | - | ||
Colorectal cancer | High | miR-92a, miR-141, let-7a, miR-1229, miR-1246, miR-150, miR-21, miR-223, miR-23a, miR-378 | miR-141, miR-320, miR-596, miR-203 | miR-106a, miR-484, miR-130b | [37,38,39,40,80,81,86] |
Low | - | miR-15a, miR-103, miR-148a, miR451 | - | ||
Hepatocellular Cancer | High | miR-500, miR-885, miR-122, miR-21, miR-223, miR-15b, miR130b, miR-101, miR-483, miR-125, miR-143, miR-215, miR-939, miR-595 | miR-718, miR-128-2 | - | [41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,82,83,84,85] |
Low | miR-200, miR-19a, miR-195 | miR-1, miR-122 | - | ||
Pancreatic cancer | High | miR-21, miR-196a, miR-18a, miR-221, miR-223, miR-20a, miR-24, miR-25, miR-99a, miR-185, miR-191, miR-1290, miR-27a, miR-642b, miR-885-5p, miR-22, miR-21, miR-483, miR-1246, miR-4644, miR-3976, and miR-4306 | miR-196a, miR-21, miR-221, miR-744 | miR-744 | [62,63,64,65,66,67,68,69,70,71,72,73,89,90] |
Low | miR-375 | - | - |
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Kawaguchi, T.; Komatsu, S.; Ichikawa, D.; Tsujiura, M.; Takeshita, H.; Hirajima, S.; Miyamae, M.; Okajima, W.; Ohashi, T.; Imamura, T.; et al. Circulating MicroRNAs: A Next-Generation Clinical Biomarker for Digestive System Cancers. Int. J. Mol. Sci. 2016, 17, 1459. https://doi.org/10.3390/ijms17091459
Kawaguchi T, Komatsu S, Ichikawa D, Tsujiura M, Takeshita H, Hirajima S, Miyamae M, Okajima W, Ohashi T, Imamura T, et al. Circulating MicroRNAs: A Next-Generation Clinical Biomarker for Digestive System Cancers. International Journal of Molecular Sciences. 2016; 17(9):1459. https://doi.org/10.3390/ijms17091459
Chicago/Turabian StyleKawaguchi, Tsutomu, Shuhei Komatsu, Daisuke Ichikawa, Masahiro Tsujiura, Hiroki Takeshita, Shoji Hirajima, Mahito Miyamae, Wataru Okajima, Takuma Ohashi, Taisuke Imamura, and et al. 2016. "Circulating MicroRNAs: A Next-Generation Clinical Biomarker for Digestive System Cancers" International Journal of Molecular Sciences 17, no. 9: 1459. https://doi.org/10.3390/ijms17091459