Long Non-Coding RNAs in Hepatitis B Virus-Related Hepatocellular Carcinoma: Regulation, Functions, and Underlying Mechanisms
Abstract
:1. Introduction
2. Dysregulation of LncRNAs in HBV-Related HCC and Their Regulation by HBV/HBx
3. Functions of LncRNAs in HCC Progression
3.1. Functions of LncRNAs in the Proliferation of HCC Cells
3.2. Functions of LncRNAs in Invasion and Metastasis of HCC Cells
3.3. Functions of LncRNAs in Death of HCC Cells
4. Underlying Mechanisms of LncRNAs in HCC Progression
4.1. Underlying Mechanisms of LncRNAs in the Proliferation of HCC Cells
4.2. Underlying Mechanisms of LncRNAs in Invasion and Metastasis of HCC Cells
4.3. Underlying Mechanisms of LncRNAs in Death of HCC Cells
5. Conclusions and Future Perspectives
Acknowledgments
Author Contributions
Conflict of interest
Abbreviations
HCC | hepatocellular carcinoma |
HBV | hepatitis B virus |
HBx | hepatitis B virus X protein |
ncRNA | non-coding RNA |
miRNA | microRNA |
lncRNA | long non-coding RNA |
CDK | cyclin-dependent kinase |
CDKI | cyclin-dependent kinase inhibitors |
EZH2 | enhancer of zeste homolog 2 |
EMT | epithelial-mensenchymal transition |
ZEB | zinc finger E-box binding homeobox |
MMP | matrix metalloproteinase |
SIRT1 | silent information regulator 2 homolog 1 |
ATG | autophagy-related gene |
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Qiu, L.; Wang, T.; Xu, X.; Wu, Y.; Tang, Q.; Chen, K. Long Non-Coding RNAs in Hepatitis B Virus-Related Hepatocellular Carcinoma: Regulation, Functions, and Underlying Mechanisms. Int. J. Mol. Sci. 2017, 18, 2505. https://doi.org/10.3390/ijms18122505
Qiu L, Wang T, Xu X, Wu Y, Tang Q, Chen K. Long Non-Coding RNAs in Hepatitis B Virus-Related Hepatocellular Carcinoma: Regulation, Functions, and Underlying Mechanisms. International Journal of Molecular Sciences. 2017; 18(12):2505. https://doi.org/10.3390/ijms18122505
Chicago/Turabian StyleQiu, Lipeng, Tao Wang, Xiuquan Xu, Yihang Wu, Qi Tang, and Keping Chen. 2017. "Long Non-Coding RNAs in Hepatitis B Virus-Related Hepatocellular Carcinoma: Regulation, Functions, and Underlying Mechanisms" International Journal of Molecular Sciences 18, no. 12: 2505. https://doi.org/10.3390/ijms18122505