Plasma Sphingolipids in Acute Pancreatitis
Abstract
:1. Introduction
2. Results
2.1. Baseline Characteristics of the Patients (Table 1)
2.2. Plasma Sphinganine Contents (pmol/mg) on the First, Third and Seventh Day after AP Onset (Figure 1)
2.3. Plasma Ceramide Contents (pmol/mg) on the First, Third and Seventh Day after AP Onset (Figure 2)
2.4. Plasma Sphingosine Contents (pmol/mg) on the First, Third and Seventh Day after AP Onset (Figure 3)
2.5. Plasma Sphingosine-1-Phosphate Contents (pmol/mg) on the First, Third and Seventh Day after AP Onset (Figure 4)
3. Discussion
4. Materials and Methods
4.1. Subjects
4.2. Serum Analyses
4.3. Contents of Plasma Sphinganine (SFA), Sphinganine-1-Phosphate (S1P) and Sphingosine (SFO)
4.4. Plasma Ceramide Content
4.5. Statistical Analysis
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Variable | Mean Value | ||
---|---|---|---|
Number of patients | n = 44 | ||
Age (y) | |||
- mean (±SD) | 45 ± 15.6 | ||
- range, no. | 23–78 | ||
Sex, no. (%) | |||
- male | 28 (63.6) | ||
- female | 16 (36.4) | ||
Acute pancreatitis aetiology: | |||
- alcohol abuse | n = 21 (47.7%) | ||
- biliary | n = 17 (38.6%) | ||
- hypertriglyceridemia | n = 2 (4.5%) | ||
- autoimmune pancreatitis | n = 2 (4.5%) | ||
- groove pancreatitis | n = 1 (2.3%) | ||
- azathioprine-induced | n = 1 (2.3%) | ||
Acute pancreatitis severity: | |||
- mild | n = 18 (40.9%) | ||
- moderately severe | n = 15 (34.1%) | ||
- severe | n = 11 (25.0%) | ||
Day 1 | Day 3 | Day 7 | |
WBC (103/mm3) (n = 4.0–10.0) | 12.89 ± 4.56 | 8.02 ± 6.36 | 7.38 ± 5.28 |
HgB (g/dL) (n = 12.5–18.0) | 15.35 ± 3.18 | 13.93 ± 4.37 | 14.21 ± 4.16 |
RBC (106/mm3) (n = 4.2–5.4) | 5.08 ± 1.09 | 5.26 ± 2.13 | 4.87 ± 2.35 |
PLT (103/mm3) (n = 130–450) | 237.26 ± 156.97 | 326.83 ± 138.46 | 190.04 ± 167.41 |
CRP (mg/L) (n ≤ 5) | 151.63 ± 80.24 | 326.35 ± 100.93 * | 40.72 ± 38.31 * |
PCT (ng/ml) (n ≤ 0.5) | 0.46 ± 2.46 | 0.23 ± 0.15 | 0.11 ± 0.73 |
Amylase (U/L) (n ≤ 90) | 651.73 ± 156.23 | 206.44 ± 63.94 * | 53.12 ± 46.63 * |
Lipase (U/L) (n ≤ 70) | 1427.62 ± 648.26 | 430.27 ± 158.73 * | 68.32 ± 45.82 * |
ALT (U/L) (n ≤ 50) | 117.85 ± 70.82 | 92.34 ± 26.03 | 64.12 ± 30.22 |
AST (U/L) (n ≤ 50) | 149.96 ± 54.12 | 110.03 ± 41.86 | 93.02 ± 23.74 |
Bilirubin (mg/dL) (n ≤ 1.1) | 1.26 ± 4.74 | 0.78 ± 2.52 | 1.02 ± 0.83 |
Na (mmol/L) (n = 135–145) | 136.04 ± 6.92 | 134.82 ± 3.15 | 133.54 ± 4.15 |
K (mmol/L) (n = 3.7–5.3) | 4.25 ± 1.76 | 4.02 ± 1.82 | 3.98 ± 1.45 |
Fibrinogen (mg/dL) (n = 200–400) | 581.16 ± 282.34 | 403.26 ± 173.83 | 390.72 ± 210.48 |
D-dimer (mg/L) (n ≤ 0.5) | 6.12 ± 2.43 | 3.36 ± 0.14 * | 1.92 ± 1.23 * |
Creatinine (mg/dL) (n = 0.5–1.0) | 1.33 ± 1.04 | 1.00 ± 1.45 | 0.8 ± 1.15 |
Urea (mg/dL) (n ≤ 50) | 37.57 ± 34.27 | 45.18 ± 23.72 | 29.36 ± 27.03 |
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Konończuk, T.; Łukaszuk, B.; Żendzian-Piotrowska, M.; Dąbrowski, A.; Krzyżak, M.; Ostrowska, L.; Kurek, K. Plasma Sphingolipids in Acute Pancreatitis. Int. J. Mol. Sci. 2017, 18, 2606. https://doi.org/10.3390/ijms18122606
Konończuk T, Łukaszuk B, Żendzian-Piotrowska M, Dąbrowski A, Krzyżak M, Ostrowska L, Kurek K. Plasma Sphingolipids in Acute Pancreatitis. International Journal of Molecular Sciences. 2017; 18(12):2606. https://doi.org/10.3390/ijms18122606
Chicago/Turabian StyleKonończuk, Tomasz, Bartłomiej Łukaszuk, Małgorzata Żendzian-Piotrowska, Andrzej Dąbrowski, Michalina Krzyżak, Lucyna Ostrowska, and Krzysztof Kurek. 2017. "Plasma Sphingolipids in Acute Pancreatitis" International Journal of Molecular Sciences 18, no. 12: 2606. https://doi.org/10.3390/ijms18122606