Role of the Vanins–Myeloperoxidase Axis in Colorectal Carcinogenesis
Abstract
:1. Introduction
1.1. Myeloperoxidase
1.2. Vanins Genes and Proteins
2. Vanins–MPO Interplay in Inflammation Processes
2.1. Mac-1 as First Connection between Vanins and MPO
2.2. Vanins and MPO as Key Players in Oxidative Stress Generation
3. Role of Chemical by Products
3.1. Vanin-Derived Cysteamine
3.2. Involvement of Taurine and Taurine Chloramine
4. Interplay in Colorectal Cancer Pathways
5. Interaction of Vanins–MPO with the Environment and Metabolism
6. Inhibition of the Vanins–MPO Axis
Targeted Compounds
7. Conclusions
Acknowledgments
Conflicts of Interest
Abbreviations
ROS | Reactive oxygen species |
MPO | Myeloperoxidase |
HOCl | Hypochlorous acid |
CysH | Cysteamine |
CysN | Cystamine |
GPI | Glycosyl-phosphatidylinositol |
Cys | Cysteamine/cystamine |
HIF-1α | Hypoxia-inducible factor 1α |
γGCS | γ–Glutamylcysteine synthetase |
GSH | Glutathione |
ADO | Cysteamine (2-aminoethanethiol) dioxygenase |
TN-Cl | Taurine chloramine |
PPARγ | Peroxisome proliferator-activated receptor γ |
MMPs | Matrix metalloproteinases |
8-OH-dG | 8-Oxo-7,8-dihydro-2′-deoxyguanosine |
TIMPs | Tissue inhibitors of metalloproteinases |
VNN1 | Vanin-1 |
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Mariani, F.; Roncucci, L. Role of the Vanins–Myeloperoxidase Axis in Colorectal Carcinogenesis. Int. J. Mol. Sci. 2017, 18, 918. https://doi.org/10.3390/ijms18050918
Mariani F, Roncucci L. Role of the Vanins–Myeloperoxidase Axis in Colorectal Carcinogenesis. International Journal of Molecular Sciences. 2017; 18(5):918. https://doi.org/10.3390/ijms18050918
Chicago/Turabian StyleMariani, Francesco, and Luca Roncucci. 2017. "Role of the Vanins–Myeloperoxidase Axis in Colorectal Carcinogenesis" International Journal of Molecular Sciences 18, no. 5: 918. https://doi.org/10.3390/ijms18050918