Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex
Abstract
:1. Introduction
2. Results
2.1. Mutational Profiling of Integrator Complex across Human Cancers
2.2. Differentially Expressed INT Subunits across Human Cancers
2.3. The Expression of INTS7, INTS8 and INTS13 Is Increased in Human Primary Tumors
3. Discussion
4. Materials and Methods
4.1. TCGA Data Source Selection and Processing for Mutation Analysis
4.2. TCGA Data Source Selection and Processing for Expression Analysis
4.3. Real-Time RT-PCR Analysis
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
Abbreviations
INT | Integrator complex |
NABP | Nucleic acid binding proteins |
TCGA | The Cancer Genome Atlas |
FC | Fold change |
FDR | False discovery rate |
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Abbreviation | Cancer Type | Mutation Analysis n | Expression Analysis n (Paired) |
---|---|---|---|
ACC | Adrenocortical carcinoma | 92 | - |
BLCA | Bladder cancer | 412 | 19 |
BRCA | Breast cancer | 1098 | 57 |
CESC | Cervical squamous cell carcinoma and endocervical adenocarcinoma | 308 | 3 |
CHOL | Cholangiocarcinoma | 51 | 9 |
COAD | Colon adenocarcinoma | 463 | 26 |
DLBC | Lymphoid neoplasm diffuse large B-cell lymphoma | 58 | - |
ESCA | Esophageal carcinoma | 185 | 13 |
GBM | Glioblastoma | 617 | 5 |
HNSC | Head and neck squamous cell carcinoma | 528 | 43 |
KICH | Kidney chromophobe carcinoma | 113 | 25 |
KIRC | Kidney renal clear cell carcinoma | 537 | 72 |
KIRP | Kidney renal papillary cell carcinoma | 291 | 32 |
LAML | Acute myeloid leukemia | 200 | - |
LIHC | Liver hepatocarcinoma | 377 | 50 |
LUAD | Lung adenocarcinoma | 585 | 58 |
LUSC | Lung squamous cell carcinoma | 504 | 51 |
OV | Ovarian cancer | 608 | - |
PAAD | Pancreas adenocarcinoma | 185 | 51 |
PCPG | Pheochromocytoma and paraganglioma | 179 | 4 |
PRAD | Prostate adenocarcinoma | 500 | 3 |
READ | Rectum adenocarcinoma | 172 | 52 |
SARC | Sarcoma | 261 | 2 |
SKCM | Skin cutaneous melanoma | 470 | - |
STAD | Stomach adenocarcinoma | 478 | - |
TGCT | Testicular germ cell tumors | 150 | - |
THCA | Thyroid cancer | 507 | 57 |
THYM | Thymoma | 124 | 2 |
UCEC | Uterine corpus endometrial carcinoma | 560 | 7 |
UCS | Uterine carcinosarcoma | 57 | - |
UVM | Uveal melanoma | 80 | - |
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Federico, A.; Rienzo, M.; Abbondanza, C.; Costa, V.; Ciccodicola, A.; Casamassimi, A. Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex. Int. J. Mol. Sci. 2017, 18, 936. https://doi.org/10.3390/ijms18050936
Federico A, Rienzo M, Abbondanza C, Costa V, Ciccodicola A, Casamassimi A. Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex. International Journal of Molecular Sciences. 2017; 18(5):936. https://doi.org/10.3390/ijms18050936
Chicago/Turabian StyleFederico, Antonio, Monica Rienzo, Ciro Abbondanza, Valerio Costa, Alfredo Ciccodicola, and Amelia Casamassimi. 2017. "Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex" International Journal of Molecular Sciences 18, no. 5: 936. https://doi.org/10.3390/ijms18050936