Adolescent Exposure to the Synthetic Cannabinoid WIN 55212-2 Modifies Cocaine Withdrawal Symptoms in Adult Mice
Abstract
:1. Introduction
2. Results
2.1. Open Field
2.2. Pre-Pulse Inhibition
2.3. Object Recognition
2.4. Elevated Plus Maze
2.5. Tail Suspension Test
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Drugs
4.3. Experimental Design
4.4. Behavioral Testing
4.4.1. Open Field
4.4.2. Pre-Pulse Inhibition
4.4.3. Object Recognition
4.4.4. Elevated Plus Maze
4.4.5. Tail Suspension
4.5. Statistical Analyses
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Measurement | Sal-Sal | Sal-Coca | WIN-Sal | WIN-Coca |
---|---|---|---|---|
Time OA (s) | 97 ± 4.7 | 23 ± 9.9 ** | 92 ± 24 | 93 ± 28 |
% time OA | 32 ± 1.6 | 8 ± 1 ** | 30 ± 2.5 | 31 ± 3 |
OA entries | 23 ± 2.2 | 11 ± 1.7 * | 21 ± 1.1 | 19 ± 2.1 |
% entries OA | 51 ± 3 | 25 ± 4.1 ** | 51 ± 3.4 | 43 ± 2.3 |
Time CA (s) | 130 ± 13 | 194 ± 11 ** | 123 ± 13 | 133 ± 13 |
CA entries | 24 ± 2.6 | 34 ± 2.8 * | 20 ± 2.6 | 24 ± 3.5 |
Total entries | 47 ± 3.1 | 45 ± 2 | 41 ± 2.5 | 43 ± 3 |
Time center (s) | 67 ± 9.2 | 78 ± 5.1 | 71 ± 4.9 | 64 ± 5.2 |
Treatment | Behavioral Testing | ||||||||
---|---|---|---|---|---|---|---|---|---|
PND | 34–47 | 48–67 | 68–69 | 70–72 | 75–79 | 80 | 81 | 82 | 83 |
Group | SAL | - | SAL | SAL | SAL | TST | |||
SAL | COCA 5 | COCA 15 | COCA 25 | OF | PPI | OR | |||
WIN | SAL | SAL | SAL | PPI | OR | EPM | |||
WIN | COCA 5 | COCA 15 | COCA 25 |
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Aguilar, M.A.; Ledesma, J.C.; Rodríguez-Arias, M.; Penalva, C.; Manzanedo, C.; Miñarro, J.; Arenas, M.C. Adolescent Exposure to the Synthetic Cannabinoid WIN 55212-2 Modifies Cocaine Withdrawal Symptoms in Adult Mice. Int. J. Mol. Sci. 2017, 18, 1326. https://doi.org/10.3390/ijms18061326
Aguilar MA, Ledesma JC, Rodríguez-Arias M, Penalva C, Manzanedo C, Miñarro J, Arenas MC. Adolescent Exposure to the Synthetic Cannabinoid WIN 55212-2 Modifies Cocaine Withdrawal Symptoms in Adult Mice. International Journal of Molecular Sciences. 2017; 18(6):1326. https://doi.org/10.3390/ijms18061326
Chicago/Turabian StyleAguilar, María A., Juan Carlos Ledesma, Marta Rodríguez-Arias, Carles Penalva, Carmen Manzanedo, José Miñarro, and M. Carmen Arenas. 2017. "Adolescent Exposure to the Synthetic Cannabinoid WIN 55212-2 Modifies Cocaine Withdrawal Symptoms in Adult Mice" International Journal of Molecular Sciences 18, no. 6: 1326. https://doi.org/10.3390/ijms18061326