Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals
Abstract
:1. Introduction: DAPKs, MAPKs
2. Cellular Functions of DAPK Family Proteins
3. Regulation of DAPK Family Proteins
4. DAPKs in Disease
5. Cross-Talk between DAPKs and ERK Signaling
6. DAPKs as Upstream Activators of Stress-Activated Protein Kinases p38 and JNK
7. DAPKs Are Therapeutic Targets of Small Molecule Inhibitors
8. Conclusions
Funding
Conflicts of Interest
References
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Name | Structure | Types of Inhibitors | IC50 |
---|---|---|---|
Alkylated 3-amino-6-phenylpyridazine | | ATP-competitive | 13, 22 mM for DAPK1 |
(4Z)-4-(3-pyridylmethylene)-2-styryl-oxazol-5-one | | ATP-competitive | 69 and 225 nM against DAPK1 and DAPK3, respectively |
(4Z)-2-[(E)-2-Phenylethenyl)-4-(3-pyridinylmethylene)-5(4H)-oxazolone (TC-DAPK6) | | ATP-competitive | 69 and 225 nM against DAPK1 and DAPK3, respectively |
6-benzyloxy-9-tert-butyl-8-phenyl-9H-purine (6d) | | ATP-competitive | 2.5 mM for DAPK1 |
HS56 | | ATP-competitive | 1 mM for DAPK3 |
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Elbadawy, M.; Usui, T.; Yamawaki, H.; Sasaki, K. Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals. Int. J. Mol. Sci. 2018, 19, 3031. https://doi.org/10.3390/ijms19103031
Elbadawy M, Usui T, Yamawaki H, Sasaki K. Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals. International Journal of Molecular Sciences. 2018; 19(10):3031. https://doi.org/10.3390/ijms19103031
Chicago/Turabian StyleElbadawy, Mohamed, Tatsuya Usui, Hideyuki Yamawaki, and Kazuaki Sasaki. 2018. "Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals" International Journal of Molecular Sciences 19, no. 10: 3031. https://doi.org/10.3390/ijms19103031