Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons
Abstract
:1. Introduction
2. Results
2.1. Experimental Set-Ups for Equal Dose Irradiation with X-Ray Photons, Plateau Protons, and Bragg-Peak Protons
2.2. The Resolution of DNA Repair Foci is Delayed After Irradiation with Bragg-Peak Protons
2.3. γH2A.X and 53BP1 Foci Differ in Size and Appearance after Different Types of Radiation
3. Discussion
4. Materials and Methods
4.1. Chemicals, Antibodies and Drugs
4.2. Cell Culture
4.3. Irradiation
4.4. Immunofluorescence Staining
4.5. Software and Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Oeck, S.; Szymonowicz, K.; Wiel, G.; Krysztofiak, A.; Lambert, J.; Koska, B.; Iliakis, G.; Timmermann, B.; Jendrossek, V. Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons. Int. J. Mol. Sci. 2018, 19, 3779. https://doi.org/10.3390/ijms19123779
Oeck S, Szymonowicz K, Wiel G, Krysztofiak A, Lambert J, Koska B, Iliakis G, Timmermann B, Jendrossek V. Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons. International Journal of Molecular Sciences. 2018; 19(12):3779. https://doi.org/10.3390/ijms19123779
Chicago/Turabian StyleOeck, Sebastian, Klaudia Szymonowicz, Gesa Wiel, Adam Krysztofiak, Jamil Lambert, Benjamin Koska, George Iliakis, Beate Timmermann, and Verena Jendrossek. 2018. "Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons" International Journal of Molecular Sciences 19, no. 12: 3779. https://doi.org/10.3390/ijms19123779