Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling
Abstract
:1. Introduction: Estrogen Receptors (ERs) and Estrogen-Related Receptors (ERRs)
2. ERs and Their Modes of Action
3. ERRs and Their Potential Ligands
4. Transcriptional Regulations by Both ERs and ERRs
5. Functions of ERs and ERRs in the Brain
5.1. Actions in the Central Regulation of Energy Homeostasis
5.2. Actions in Learning and Memory
5.3. Actions in Social Behaviors
6. Concluding Remark
Acknowledgments
Author Contributions
Conflicts of Interest
Abbreviations
AgRP | Agouti-Related Peptide |
Akt | Protein Kinase B |
ARC | Arcuate nucleus Of Hypothalamus |
BDNF | Brain-Derived Neurotrophic Factor |
β-OX | β-Oxidation |
ChIP | Chromatin Immunoprecipitation |
CYP19 | Aromatase |
DBD | DNA Binding Domain |
dmPFC | Dorsomedial Prefrontal Cortex |
DPN | Diaryl-Propionitrile |
E2 | 17β-Estradiol |
ER | Estrogen Receptor |
ERE | Estrogen Response Element |
ERR | Estrogen-Related Receptor |
ERRE | Estrogen-Related Response Element |
ERK | Extracellular Signal-Regulated Kinase |
ETC | Electron Transport Chain |
FAO | Fatty Acid Oxidation |
FNDC5 | Fibronectin Type III Domain Containing 5 |
GPER | G protein-Coupled Estrogen Receptor |
HFD | High Fat Diet |
IHC | Immunohistochemistry |
LTP | Long-Term Potenciation |
MeA | Medial Amygdala |
MHRE | Multiple-Hormone Response element |
MitoBio | Mitochondrial Biogenesis |
NPY | Neuropeptide |
NTS | Nucleus of Solitary Tract |
Oxphos | Oxidative Phosphorylation |
PV | Parvalbumin |
PGC | Proliferator-Activated Receptor γ Coactivator |
PI3K | Phosphatidyl Inositide 3-Kinase |
POMC | Pro-Opiomelanocortin |
PPT | Propyl-Pyrazole Triol |
VMH | Ventromedial Nucleus of Hypothalamus |
VTA | Ventral Tegmental Area |
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Saito, K.; Cui, H. Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling. Int. J. Mol. Sci. 2018, 19, 1091. https://doi.org/10.3390/ijms19041091
Saito K, Cui H. Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling. International Journal of Molecular Sciences. 2018; 19(4):1091. https://doi.org/10.3390/ijms19041091
Chicago/Turabian StyleSaito, Kenji, and Huxing Cui. 2018. "Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling" International Journal of Molecular Sciences 19, no. 4: 1091. https://doi.org/10.3390/ijms19041091