Next Article in Journal
The Expression Pattern of PLIN2 in Differentiated Adipocytes from Qinchuan Cattle Analysis of Its Protein Structure and Interaction with CGI-58
Previous Article in Journal
ScFvs as Allosteric Inhibitors of VEGFR-2: Novel Tools to Harness VEGF Signaling
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 19
Issue 5
10.3390/ijms19051335
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Dietary α-Mangostin Provides Protective Effects against Acetaminophen-Induced Hepatotoxicity in Mice via Akt/mTOR-Mediated Inhibition of Autophagy and Apoptosis

by
Xiao-tong Yan
1,
Yin-shi Sun
1,2,
Shen Ren
1,
Li-chun Zhao
3,
Wen-cong Liu
1,
Chen Chen
4,
Zi Wang
1 and
Wei Li
1,*
1
College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China
2
Institute of Special Wild Economic Animals and Plant, CAAS, Changchun 132109, China
3
College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530011, China
4
School of Biomedical Sciences, University of Queensland, Brisbane 4072, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(5), 1335; https://doi.org/10.3390/ijms19051335
Submission received: 30 March 2018 / Revised: 25 April 2018 / Accepted: 26 April 2018 / Published: 1 May 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
Browse Figures
Versions Notes

Abstract

Acetaminophen overdose-induced hepatotoxicity is the most common cause of acute liver failure in many countries. Previously, alpha-mangostin (α-MG) has been confirmed to exert protective effects on a variety of liver injuries, but the protective effect on acetaminophen-induced acute liver injury (ALI) remains largely unknown. This work investigated the regulatory effect and underlying cellular mechanisms of α-MG action to attenuate acetaminophen-induced hepatotoxicity in mice. The increased serum aminotransferase levels and glutathione (GSH) content and reduced malondialdehyde (MDA) demonstrated the protective effect of α-MG against acetaminophen-induced hepatotoxicity. In addition, α-MG pretreatment inhibited increases in tumor necrosis factor (TNF-α) and interleukin-1β (IL-1β) caused by exposure of mice to acetaminophen. In liver tissues, α-MG inhibited the protein expression of autophagy-related microtubule-associated protein light chain 3 (LC3) and BCL2/adenovirus E1B protein-interacting protein 3 (BNIP3). Western blotting analysis of liver tissues also proved evidence that α-MG partially inhibited the activation of apoptotic signaling pathways via increasing the expression of Bcl-2 and decreasing Bax and cleaved caspase 3 proteins. In addition, α-MG could in part downregulate the increase in p62 level and upregulate the decrease in p-mTOR, p-AKT and LC3 II /LC3 I ratio in autophagy signaling pathways in the mouse liver. Taken together, our findings proved novel perspectives that detoxification effect of α-MG on acetaminophen-induced ALI might be due to the alterations in Akt/mTOR pathway in the liver.
Keywords: α-mangostin; acetaminophen; acute liver injury; apoptosis; autophagy α-mangostin; acetaminophen; acute liver injury; apoptosis; autophagy
Graphical Abstract

Share and Cite

MDPI and ACS Style

Yan, X.-t.; Sun, Y.-s.; Ren, S.; Zhao, L.-c.; Liu, W.-c.; Chen, C.; Wang, Z.; Li, W. Dietary α-Mangostin Provides Protective Effects against Acetaminophen-Induced Hepatotoxicity in Mice via Akt/mTOR-Mediated Inhibition of Autophagy and Apoptosis. Int. J. Mol. Sci. 2018, 19, 1335. https://doi.org/10.3390/ijms19051335

AMA Style

Yan X-t, Sun Y-s, Ren S, Zhao L-c, Liu W-c, Chen C, Wang Z, Li W. Dietary α-Mangostin Provides Protective Effects against Acetaminophen-Induced Hepatotoxicity in Mice via Akt/mTOR-Mediated Inhibition of Autophagy and Apoptosis. International Journal of Molecular Sciences. 2018; 19(5):1335. https://doi.org/10.3390/ijms19051335

Chicago/Turabian Style

Yan, Xiao-tong, Yin-shi Sun, Shen Ren, Li-chun Zhao, Wen-cong Liu, Chen Chen, Zi Wang, and Wei Li. 2018. "Dietary α-Mangostin Provides Protective Effects against Acetaminophen-Induced Hepatotoxicity in Mice via Akt/mTOR-Mediated Inhibition of Autophagy and Apoptosis" International Journal of Molecular Sciences 19, no. 5: 1335. https://doi.org/10.3390/ijms19051335

APA Style

Yan, X.-t., Sun, Y.-s., Ren, S., Zhao, L.-c., Liu, W.-c., Chen, C., Wang, Z., & Li, W. (2018). Dietary α-Mangostin Provides Protective Effects against Acetaminophen-Induced Hepatotoxicity in Mice via Akt/mTOR-Mediated Inhibition of Autophagy and Apoptosis. International Journal of Molecular Sciences, 19(5), 1335. https://doi.org/10.3390/ijms19051335

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop