Genomics of Fibromuscular Dysplasia
Abstract
:1. Definition and Main Features of Fibromuscular Dysplasia (FMD)
2. Classical Aetiological Hypothesis
2.1. Female Hormones
2.2. Traumatic Theory
2.3. Intramural Ischemia
2.4. Smoking
3. FMD as a Genetic Disease
3.1. Familial Forms of FMD
3.2. Genetic Susceptibility to FMD
3.3. Overlap with Genetic Syndromes
4. Challenges of the Genetic Investigation of FMD
5. Current Knowledge from Genetic Studies
5.1. Candidate Gene Studies
5.2. Exome Studies
5.2.1. Genetic Investigation of FMD Using Exome Sequencing in Families
5.2.2. Potential Genetic Link between the Grange Syndrome and FMD
5.3. Non-Hypothesis Driven Genetic Association Study
5.4. Insights and Limitations from Functional Genomics at PHACTR1 Locus
6. Ongoing Studies
7. Future Research Directions and Clinical Perspectives
Conflicts of Interest
References
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Focal atherosclerotic lesions |
Inflammatory arterial diseases:
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Arterial diseases of monogenic origin:
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Di Monaco, S.; Georges, A.; Lengelé, J.-P.; Vikkula, M.; Persu, A. Genomics of Fibromuscular Dysplasia. Int. J. Mol. Sci. 2018, 19, 1526. https://doi.org/10.3390/ijms19051526
Di Monaco S, Georges A, Lengelé J-P, Vikkula M, Persu A. Genomics of Fibromuscular Dysplasia. International Journal of Molecular Sciences. 2018; 19(5):1526. https://doi.org/10.3390/ijms19051526
Chicago/Turabian StyleDi Monaco, Silvia, Adrien Georges, Jean-Philippe Lengelé, Miikka Vikkula, and Alexandre Persu. 2018. "Genomics of Fibromuscular Dysplasia" International Journal of Molecular Sciences 19, no. 5: 1526. https://doi.org/10.3390/ijms19051526