Role of mTOR Complexes in Neurogenesis
Abstract
:1. Introduction
2. Overview of Cortical and Postnatal Neurogenesis
3. The mTOR Signaling Network
4. mTOR Complexes in Cell Cycle Regulation
5. Activation of mTOR Complexes Promotes Neural Stem Cell Differentiation
6. Hyperactivation of mTORC1 Results in Aberrant Migration
7. Role of mTORC1 in Neurite Development and Synapse Formation
8. Conclusions
Author Contributions
Acknowledgments
Conflicts of Interest
Abbreviations
4E-BP1 | Translation initiation factor 4e binding protein |
4E-BP2 | 4E- protein phosphatase 2 |
Akt | Protein Kinase B |
ASD | Autism Spectrum Disorder |
CDK4 | Cyclin-dependent kinase 4 |
DEPTOR | DEP domain-containing mTOR interacting protein |
DISC1 | Disrupted-in-Schizophrenia 1 |
EGF | Epidermal growth factor |
eIF-4e | Eukaryotic translation initiaton 4e |
Erk | Extracellular signal related kinase |
ESC | Embryonic stem cells |
FOXO | Forkhead box class O |
Gsk-3β | Glycogen synthase kinase 3 beta |
IGF | Insulin-like growth factor |
MDM2 | Mouse double minute 2 homolog |
MLST8 | mTOR associated protein LST8 |
mSin1 | Mammalian stress-activated protein kinase-interacting protein |
mTOR | mammalian target of rapamycin |
mTORC1 | mammalian target of rapamycin complex 1 |
mTORC2 | mammalian target of rapamycin complex 2 |
NMDA | N-methyl-D-aspartate |
NSC | Neural stem cell |
OB | Olfactory bulb |
P21Cip1/WAF-1 | Cyclin dependent kinase inhibitor 1 |
PCNA | Proliferating cell nuclear antigen |
PDK1 | Phosphoinosidite-dependent kinase 1 |
PH PI3K | Pleckstrin homology Phosphoinositide 3 kinase |
Pras40 | Proline-rich AKT substrate |
PTEN | Phosphatase and tensin homolog |
Raptor | Regulatory-associated protein of mTOR |
RGC | Radial glial cell |
Rheb | Ras homolog enriched in brain |
Rictor | Rapamycin-insensitive companion of mTOR |
RMS | Rostral migratory stream |
S6k1 | S6 Kinase 1 |
SVZ | Sub ventricular zone |
TAC | Transit amplifying cell |
Tbr2 | T-box brain protein 2 |
TS | Tuberous sclerosis |
TSC1 | Tuberous sclerosis complex 1 |
TSC2 | Tuberous sclerosis complex 2 |
UTX | Ubiquitously transcribed tetratricopeptide repeat, X chromosome |
VZ | Ventricular zone |
Ypk1 | Yeast serine/threonine protein kinase 1 |
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LiCausi, F.; Hartman, N.W. Role of mTOR Complexes in Neurogenesis. Int. J. Mol. Sci. 2018, 19, 1544. https://doi.org/10.3390/ijms19051544
LiCausi F, Hartman NW. Role of mTOR Complexes in Neurogenesis. International Journal of Molecular Sciences. 2018; 19(5):1544. https://doi.org/10.3390/ijms19051544
Chicago/Turabian StyleLiCausi, Francesca, and Nathaniel W. Hartman. 2018. "Role of mTOR Complexes in Neurogenesis" International Journal of Molecular Sciences 19, no. 5: 1544. https://doi.org/10.3390/ijms19051544