Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems
Abstract
:1. Introduction
2. The Dopaminergic System
3. The Serotonergic System
4. Cross-Talk between the Dopaminergic and Serotonergic Systems
5. Conclusions
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Neuronal Cluster | Function | Ref. |
---|---|---|
Dopaminergic neurons | ||
PAM | Sugar reward, reward signaling, long-term and short-term memory formation, aversive memory formation, negative geotaxis, promote wakefulness, foraging behavior, promote oviposition preference | [22,71,77,138,139,140,141] |
PAL | Involved in mating drive | [142,143,144] |
PPL1 | Aversive memory formation, sugar reward and nutrient value, negative geotaxis, modulate sleep, Inhibit oviposition preference | [1,3,4,5,7,11,12,145] |
PPM2 | Protein consumption preference | [146] |
PPM3 | Aggression phenotype Modulate sleep, promote oviposition preference | [7,14,15,16] |
T1 | Aggression phenotype | [21] |
SOG | Proboscis extension in response to satiety state | [147] |
Serotonergic neurons | ||
PLP | Aggression | [148] |
PMPM | Modulate anesthesia resistant memory and sleep | [149,150] |
CSD | Modulate ethanol perception | [111] |
SEL | Long term memory formation | [95] |
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Kasture, A.S.; Hummel, T.; Sucic, S.; Freissmuth, M. Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems. Int. J. Mol. Sci. 2018, 19, 1788. https://doi.org/10.3390/ijms19061788
Kasture AS, Hummel T, Sucic S, Freissmuth M. Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems. International Journal of Molecular Sciences. 2018; 19(6):1788. https://doi.org/10.3390/ijms19061788
Chicago/Turabian StyleKasture, Ameya Sanjay, Thomas Hummel, Sonja Sucic, and Michael Freissmuth. 2018. "Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems" International Journal of Molecular Sciences 19, no. 6: 1788. https://doi.org/10.3390/ijms19061788