Leptin-induced Trafficking of KATP Channels: A Mechanism to Regulate Pancreatic β-cell Excitability and Insulin Secretion
Abstract
:1. Introduction
2. Leptin Increases KATP Channel Conductance in β-Cells
3. Leptin Increases KATP Channel Surface Density
4. KATP Channel Trafficking Signaling Molecules
4.1. AMPK
4.2. CaMKKβ
4.3. PI3 Kinase and TRPC4 Channels
4.4. NMDA Receptors
4.5. Actin Remodeling Molecules
4.5.1. PKA
4.5.2. PTEN
5. The Role of Glucose and its Interplay with Leptin in KATP Channel Trafficking Regulation
6. Future Questions
7. Concluding Remarks
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Cochrane, V.; Shyng, S.-L. Leptin-induced Trafficking of KATP Channels: A Mechanism to Regulate Pancreatic β-cell Excitability and Insulin Secretion. Int. J. Mol. Sci. 2019, 20, 2660. https://doi.org/10.3390/ijms20112660
Cochrane V, Shyng S-L. Leptin-induced Trafficking of KATP Channels: A Mechanism to Regulate Pancreatic β-cell Excitability and Insulin Secretion. International Journal of Molecular Sciences. 2019; 20(11):2660. https://doi.org/10.3390/ijms20112660
Chicago/Turabian StyleCochrane, Veronica, and Show-Ling Shyng. 2019. "Leptin-induced Trafficking of KATP Channels: A Mechanism to Regulate Pancreatic β-cell Excitability and Insulin Secretion" International Journal of Molecular Sciences 20, no. 11: 2660. https://doi.org/10.3390/ijms20112660