Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis
Abstract
:1. Introduction
2. PI3K Signaling and Akt Isoforms in Macrophages
Macrophage Phenotypes in Atherosclerosis
3. Impact of Akt Signaling on Macrophage Polarization
4. Macrophage Apoptosis and Atherosclerosis
5. PI3K/Akt Signaling and Cell Survival
6. Double Akt Isoform Knockout Mice Highlight Critical Pro-Survival Role of Akt1
7. Loss of Two Akt Isoforms in Hematopoietic Cells Is Detrimental for Their Survival
8. Mice with a Single Akt Isoform in Hematopoietic Cells Exhibited Low Levels of White Blood Cells, B-Cells, and Monocytes, and Increased Apoptosis in Monocytes and Macrophages
Author Contributions
Funding
Conflicts of Interest
References
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Linton, M.F.; Moslehi, J.J.; Babaev, V.R. Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis. Int. J. Mol. Sci. 2019, 20, 2703. https://doi.org/10.3390/ijms20112703
Linton MF, Moslehi JJ, Babaev VR. Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis. International Journal of Molecular Sciences. 2019; 20(11):2703. https://doi.org/10.3390/ijms20112703
Chicago/Turabian StyleLinton, MacRae F., Javid J. Moslehi, and Vladimir R. Babaev. 2019. "Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis" International Journal of Molecular Sciences 20, no. 11: 2703. https://doi.org/10.3390/ijms20112703