Metabolomic Studies of Tissue Injury in Nonhuman Primates Exposed to Gamma-Radiation
Abstract
:1. Introduction
2. Results
2.1. Untargeted Metabolomics Analysis Identifies Changes in the Tissue Metabolome of the NHPs Exposed to Radiation
2.2. Metabolite Alterations in the Kidney and Liver Profiles as Indicators of Radiation-Induced Tissue Damage
2.3. Generic Markers of Ionizing Radiation Exposure Across Multiple Tissue Types
3. Discussion
4. Materials and Methods
4.1. Animals and Animal Care
4.2. Radiation Exposure
4.3. Tissue Sample Collection
4.4. Sample Preparation and LC-MS Analyses
4.5. Statistical Analyses
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Cheema, A.K.; Mehta, K.Y.; Rajagopal, M.U.; Wise, S.Y.; Fatanmi, O.O.; Singh, V.K. Metabolomic Studies of Tissue Injury in Nonhuman Primates Exposed to Gamma-Radiation. Int. J. Mol. Sci. 2019, 20, 3360. https://doi.org/10.3390/ijms20133360
Cheema AK, Mehta KY, Rajagopal MU, Wise SY, Fatanmi OO, Singh VK. Metabolomic Studies of Tissue Injury in Nonhuman Primates Exposed to Gamma-Radiation. International Journal of Molecular Sciences. 2019; 20(13):3360. https://doi.org/10.3390/ijms20133360
Chicago/Turabian StyleCheema, Amrita K., Khyati Y. Mehta, Meena U. Rajagopal, Stephen Y. Wise, Oluseyi O. Fatanmi, and Vijay K. Singh. 2019. "Metabolomic Studies of Tissue Injury in Nonhuman Primates Exposed to Gamma-Radiation" International Journal of Molecular Sciences 20, no. 13: 3360. https://doi.org/10.3390/ijms20133360