Next Article in Journal
Can We Still Trust Docking Results? An Extension of the Applicability of DockBench on PDBbind Database
Next Article in Special Issue
Setting Fire to ESA and EMA Resistance: New Targeted Treatment Options in Lower Risk Myelodysplastic Syndromes
Previous Article in Journal
RcAP1, a Homolog of APETALA1, is Associated with Flower Bud Differentiation and Floral Organ Morphogenesis in Rosa chinensis
Previous Article in Special Issue
Targeting Tyrosine Kinases in Acute Myeloid Leukemia: Why, Who and How?
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 20
Issue 14
10.3390/ijms20143559
Review Report
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Autophagy: New Insights into Mechanisms of Action and Resistance of Treatment in Acute Promyelocytic leukemia

Int. J. Mol. Sci. 2019, 20(14), 3559; https://doi.org/10.3390/ijms20143559
by Mohammad Amin Moosavi 1 and Mojgan Djavaheri-Mergny 2,3,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2019, 20(14), 3559; https://doi.org/10.3390/ijms20143559
Submission received: 28 June 2019 / Revised: 15 July 2019 / Accepted: 18 July 2019 / Published: 20 July 2019
(This article belongs to the Special Issue Drug Resistance in Hematologic Malignancies)

Round  1

Reviewer 1 Report

This is a good review related to the impact of autophagy on the mechanisms of action of ATRA and ATO in acute promyelocytic leukemia. The content is appropriate, although I have some comments:

On the Introduction, I would include a figure of the oncogenic mechanisms of PML-RAR, in order to understand better the effects of the treatments. 

Another figure related to the regulation of autophagy in APL cells will be very useful to understand the other figure related to the treatments. You can combine the two figures. 

Thank you very much for your interesting manuscript. 



Author Response

Thanks for the suggestions

As requested by the referee, we includedc the oncogenic mechanism of PML-RARA in the figure 1 (please see white boxes in the attached figure 1)


As requested by the referee, we  added « the regulation of autophagy in APL » in the figure 3 ( please see attached figure 3 "downregulation of ATG proteins and p62".


thank you



Author Response File: Author Response.pdf

Reviewer 2 Report

This is a well written and timely review on autophagy in APL.   The contrasts and similarities between the two therapeutic approaches to treatment using ATRA or Arsenic are well described and illustrated. 

My only comment would be that whilst the authors mention a discussion on the role ot autophagy in resistance - it is not a clear section in the same way that differentiation syndrome is covered. 

Author Response

Thanks for the suggestions

In fact, little is known  in the literature on the  role of autophagy and ATG proteins in  the development of differentiation syndrome in APL  patients.

This aspect was added in the manuscript text in the lines 320-322: “Likewise, the clinical significance of the pro-survival role of some ATG proteins in the development of differentiation syndrome deserves to be investigated” and in the lines  358-359:” Under this condition, whether or not microRNA-dependent control of autophagy contributes to the development of differentiation syndrome warrants to be investigated”.


thank you

Back to TopTop