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Review

Selecting an Appropriate Animal Model of Depression

by
Yuanzhen Hao
1,
Huixiang Ge
2,
Mengyun Sun
2 and
Yun Gao
2,*
1
Joint Program of Nanchang University and Queen Mary University of London, Nanchang 330006, China
2
Department of Physiology, The Basic Medical College of Nanchang University, Nanchang 330006, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(19), 4827; https://doi.org/10.3390/ijms20194827
Submission received: 15 September 2019 / Accepted: 26 September 2019 / Published: 28 September 2019
(This article belongs to the Special Issue Animal Models of Parkinson's Disease and Related Disorders)
Versions Notes

Abstract

Depression has become one of the most severe psychiatric disorders and endangers the health of living beings all over the world. In order to explore the molecular mechanism that underlies depression, different kinds of animal models of depression are used in laboratory experiments. However, a credible and reasonable animal model that is capable of imitating the pathologic mechanism of depression in mankind has yet to be found, resulting in a barrier to further investigation of depression. Nevertheless, it is possible to explain the pathologic mechanism of depression to a great extent by a rational modeling method and behavioral testing. This review aims to provide a reference for researchers by comparing the advantages and disadvantages of some common animal depression models.
Keywords: depression; animal model; behavior test depression; animal model; behavior test

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MDPI and ACS Style

Hao, Y.; Ge, H.; Sun, M.; Gao, Y. Selecting an Appropriate Animal Model of Depression. Int. J. Mol. Sci. 2019, 20, 4827. https://doi.org/10.3390/ijms20194827

AMA Style

Hao Y, Ge H, Sun M, Gao Y. Selecting an Appropriate Animal Model of Depression. International Journal of Molecular Sciences. 2019; 20(19):4827. https://doi.org/10.3390/ijms20194827

Chicago/Turabian Style

Hao, Yuanzhen, Huixiang Ge, Mengyun Sun, and Yun Gao. 2019. "Selecting an Appropriate Animal Model of Depression" International Journal of Molecular Sciences 20, no. 19: 4827. https://doi.org/10.3390/ijms20194827

APA Style

Hao, Y., Ge, H., Sun, M., & Gao, Y. (2019). Selecting an Appropriate Animal Model of Depression. International Journal of Molecular Sciences, 20(19), 4827. https://doi.org/10.3390/ijms20194827

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