Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma
Abstract
:1. Introduction
2. Effect of Thyroid Hormone on the Role of Oxidative Stress-Related microRNAs in Liver
2.1. Oxidative Stress Promotes HCC Progression
2.2. Roles of microRNAs Correlated with Oxidative Stress in HCC
2.3. Role of Thyroid Hormone and Its Receptor in HCC
2.4. Thyroid Hormone Induces an Anti-Oxidative Stress Effect in Hepatocytes Mediated by microRNAs
2.5. Thyroid Hormone Promotes Oxidative Stress in Hepatocytes by Regulating microRNAs
3. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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microRNA | Correlative with Oxidative Stress | Ref. |
---|---|---|
miR-34a-5p miR-1915-3p miR-638 miR-150-3p | Associated with oxidative stress-related apoptosis | [30] |
miR-92 | Correlated positively with telomerase activity, 8-OHdG Target to anti-oxidative gene Sirt1 | [32] |
miR-199a/b | Prevents the liver cell oxidative stress induced by bile acid Target to Sirt1 | [33] |
miR-122 | Correlative with HCV/ HBV infection Positive association with antioxidant enzyme NQO1 | [34] [35] |
miR-26a | Affecting liver lipid metabolism | [36] |
miR-155 | Affecting liver lipid metabolism | [37] |
miR-214 | Associated with oxidative stress-related apoptosis Target to ATF4 and EZH2 | [38] [39] |
miR-200 | Target to p38α and repression anti-oxidative gene Nrf2 | [40] |
miR-181 | Target to Sirt1 and impair insulin sensitivity | [41] |
miR-128 | Target to DJ-1 Target to Sirt1 | [42] [43] |
miR-29a/c | Controls the hepatic lipogenic process | [44] |
miR-21 | Leading to mitochondrial ROS accumulation | [45] |
miR-196 | Downregulates Bach1, and inhibition of HCV expression | [46] |
miRNAs Positively Affected by Thyroid Hormones * | ||||||||
---|---|---|---|---|---|---|---|---|
HepG2-TRα1 | HepG2-TRβ1 | |||||||
TH/microRNAs | MicroRNA | Fold | HCC/ROS Ref. | TH | MicroRNA | Fold | HCC/ROS Ref. | TH |
Three times repetitive experiments | miR-122 | 10.54 | [35,77] | [78] | miR-29c | 4.21 | [44,79] | |
miR-152 | 3.42 | miR-214 | 3.50 | [38,80,81] | [38] | |||
miR-139-5p | 10.38 | miR-202 | 2.41 | |||||
miR-128a | 71.90 | [43] | ||||||
miR-139-3p | 3.85 | |||||||
miR-548d-3p | 3.09 | |||||||
miR-140-3p | 2.77 | |||||||
Two times repetitive experiments | miR-143 | 6.20 | miR-193b | 2.99 | ||||
miR-210 | 5.22 | miR-139-5p | 3.12 | |||||
miR-365 | 5.53 | miR-210 | 2.52 | |||||
miR-135b | 4.38 | miR-323-3p | 4.12 | |||||
miR-148a | 5.16 | miR-22 | 2.54 | |||||
miR-193b | 3.30 | miR-29a | 2.18 | [44,82] | ||||
miR-125a-3p | 2.92 | miR-29b-1 * | 3.30 | |||||
miR-29a | 3.15 | [44,82] | miR-193a-3p | 3.34 | ||||
miR-24 | 2.40 | [83] | [78] | miR-139-3p | 2.22 | |||
miR-372 | 3.57 | miR-510 | 2.32 | [75,78] | ||||
miR-372 | 5.07 | miR-21 * | 2.22 | [45,84,85,86] | ||||
miR-188-3p | 3.05 | |||||||
miR-100 | 4.11 | |||||||
miR-126 | 2.35 | |||||||
miR-21 | 3.30 | [45,84,85,86] | [75,78] |
miRNAs Negativity Affected by Thyroid Hormones * | ||||||||
---|---|---|---|---|---|---|---|---|
HepG2-TRα1 | HepG2-TRβ1 | |||||||
TH/microRNAs | MicroRNA | Fold | HCC/ROS Ref. | TH | MicroRNA | Fold | HCC/ROS Ref. | TH |
Three times repetitive experiments | miR-184 | 0.22 | miR-455-3p | 0.22 | ||||
miR-455-3p | 0.12 | miR-148a | 0.36 | |||||
miR-499-3p | 0.20 | miR-425 * | 0.24 | |||||
miR-221 | 0.33 | miR-187 | 0.27 | |||||
miR-181b | 0.30 | [87] | miR-429 | 0.41 | ||||
miR-130b | 0.34 | [76] | ||||||
miR-149 | 0.35 | |||||||
miR-17 | 0.34 | [85] | [74] | |||||
Two times repetitive experiments | miR-425 * | 0.22 | miR-106a | 0.23 | ||||
miR-20a | 0.31 | miR-199a-5p | 0.22 | [33,87,88] | [38] | |||
miR-377 | 0.42 | miR-548d-5p | 0.24 | |||||
miR-15b | 0.43 | miR-146a | 0.31 | |||||
miR-516a-5p | 0.29 | miR-221 | 0.27 | |||||
miR-652 | 0.49 | miR-30a * | 0.35 | |||||
miR-550 | 0.26 | miR-499-3p | 0.32 | |||||
miR-18a | 0.23 | miR-888 | 0.27 | |||||
miR-106a | 0.28 | miR-100 | 0.33 | |||||
miR-628-3p | 0.34 | miR-339-3p | 0.45 | |||||
miR-146a | 0.36 | miR-18a | 0.39 | |||||
miR-181c | 0.41 | [87] | miR-18b | 0.24 | ||||
miR-92a | 0.36 | [32,89,90] | miR-10a | 0.25 | ||||
miR-106b | 0.38 | miR-421 | 0.30 | |||||
miR-487b | 0.35 | miR-525-3p | 0.41 | [74,85] | ||||
miR-570 | 0.40 | miR-17 | 0.37 | [85,90] | [74] | |||
let-7d | 0.44 | miR-542-5p | 0.33 | [46,85] | ||||
miR-15b * | 0.44 | miR-196a * | 0.42 | [46] | ||||
miR-196b | 0.46 | |||||||
miR-19a | 0.46 | [87] | ||||||
miR-181d | 0.32 | |||||||
miR-20b | 0.40 |
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Huang, P.-S.; Wang, C.-S.; Yeh, C.-T.; Lin, K.-H. Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma. Int. J. Mol. Sci. 2019, 20, 5220. https://doi.org/10.3390/ijms20205220
Huang P-S, Wang C-S, Yeh C-T, Lin K-H. Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma. International Journal of Molecular Sciences. 2019; 20(20):5220. https://doi.org/10.3390/ijms20205220
Chicago/Turabian StyleHuang, Po-Shuan, Chia-Siu Wang, Chau-Ting Yeh, and Kwang-Huei Lin. 2019. "Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma" International Journal of Molecular Sciences 20, no. 20: 5220. https://doi.org/10.3390/ijms20205220
APA StyleHuang, P. -S., Wang, C. -S., Yeh, C. -T., & Lin, K. -H. (2019). Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma. International Journal of Molecular Sciences, 20(20), 5220. https://doi.org/10.3390/ijms20205220