The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus

Hajdamowicz, Natalia H; Hull, Rebecca C; Foster, Simon J; Condliffe, Alison M

doi:10.3390/ijms20225561

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The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus

by

Natalia H Hajdamowicz

^1,2,

Rebecca C Hull

^1,2,

Simon J Foster

² and

Alison M Condliffe

^1,2,*

¹

Department of Infection, Immunity and Cardiovascular Diseases, University of Sheffield, Beech Hill Road, Sheffield S10 2TN, UK

²

Florey Institute, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2019, 20(22), 5561; https://doi.org/10.3390/ijms20225561

Submission received: 9 October 2019 / Revised: 26 October 2019 / Accepted: 31 October 2019 / Published: 7 November 2019

(This article belongs to the Special Issue The Impact of Hypoxia on Neutrophil Signaling and Function)

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Abstract

Neutrophils are key to host defence, and impaired neutrophil function predisposes to infection with an array of pathogens, with Staphylococcus aureus a common and sometimes life-threatening problem in this setting. Both infiltrating immune cells and replicating bacteria consume oxygen, contributing to the profound tissue hypoxia that characterises sites of infection. Hypoxia in turn has a dramatic effect on both neutrophil bactericidal function and the properties of S. aureus, including the production of virulence factors. Hypoxia thereby shapes the host–pathogen interaction and the progression of infection, for example promoting intracellular bacterial persistence, enabling local tissue destruction with the formation of an encaging abscess capsule, and facilitating the establishment and propagation of bacterial biofilms which block the access of host immune cells. Elucidating the molecular mechanisms underlying host–pathogen interactions in the setting of hypoxia will enable better understanding of persistent and recalcitrant infections due to S. aureus and may uncover novel therapeutic targets and strategies.

Keywords: neutrophils; host-pathogen interaction; hypoxia; Staphylococcus aureus

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MDPI and ACS Style

Hajdamowicz, N.H.; Hull, R.C.; Foster, S.J.; Condliffe, A.M. The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus. Int. J. Mol. Sci. 2019, 20, 5561. https://doi.org/10.3390/ijms20225561

AMA Style

Hajdamowicz NH, Hull RC, Foster SJ, Condliffe AM. The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus. International Journal of Molecular Sciences. 2019; 20(22):5561. https://doi.org/10.3390/ijms20225561

Chicago/Turabian Style

Hajdamowicz, Natalia H, Rebecca C Hull, Simon J Foster, and Alison M Condliffe. 2019. "The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus" International Journal of Molecular Sciences 20, no. 22: 5561. https://doi.org/10.3390/ijms20225561

APA Style

Hajdamowicz, N. H., Hull, R. C., Foster, S. J., & Condliffe, A. M. (2019). The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus. International Journal of Molecular Sciences, 20(22), 5561. https://doi.org/10.3390/ijms20225561

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus

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