Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus
Abstract
:1. Introduction
2. Results
2.1. Treatment with GH Immediately after Lesion plus Rehabilitative Therapy Produced the Functional Recovery of the Motor Impairment Induced by the Cortical Ablation
2.2. Cortical Cell Proliferative Response in Animals Treated with GH or Vehicle after Motor Cortical Ablation
2.3. Nestin Expression in the Striatum and Thalamus of Animals Treated with GH or Vehicle after Cortical Ablation
2.4. Actin Expression in the Striatum and Thalamus of Animals Treated with GH or Vehicle after Cortical Ablation
3. Discussion
4. Materials and Methods
4.1. Experimental Design and Behavioral Test
4.2. Frontal Motor Cortex Ablation
4.3. Treatment with GH and Rehabilitative Therapy
4.4. BrdU Administration
4.5. Immunofluorescence
4.6. Immunohistochemistry
4.7. Quantitative Analysis
4.8. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Heredia, M.; Rodríguez, N.; Sánchez Robledo, V.; Criado, J.M.; de la Fuente, A.; Devesa, J.; Devesa, P.; Sánchez Riolobos, A. Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus. Int. J. Mol. Sci. 2019, 20, 5770. https://doi.org/10.3390/ijms20225770
Heredia M, Rodríguez N, Sánchez Robledo V, Criado JM, de la Fuente A, Devesa J, Devesa P, Sánchez Riolobos A. Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus. International Journal of Molecular Sciences. 2019; 20(22):5770. https://doi.org/10.3390/ijms20225770
Chicago/Turabian StyleHeredia, Margarita, Natalia Rodríguez, Virginia Sánchez Robledo, José María Criado, Antonio de la Fuente, Jesús Devesa, Pablo Devesa, and Adelaida Sánchez Riolobos. 2019. "Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus" International Journal of Molecular Sciences 20, no. 22: 5770. https://doi.org/10.3390/ijms20225770