Small Molecule Inhibitors Targeting the Heat Shock Protein System of Human Obligate Protozoan Parasites
Abstract
:1. Introduction
2. Hsp90 Family
2.1. Hsp90–Hsp70 Chaperone Pathway
2.2. Hsp90 as a Drug Target
2.3. Small Molecule Inhibitors of Hsp90
2.4. Plasmodial Hsp90 as a Drug Target
2.5. Leishmanial Hsp90 as a Drug Target
2.6. Toxoplasma Hsp90 as a Drug Target
2.7. Trypanosoma Hsp90 as Drug Targets
3. Hsp100 Family
Parasitic Hsp100 as Drug Targets
4. Hsp60 Family
Targeting Parasite Hsp60
5. Hsp70 Chaperone System
P. falciparum Hsp70 as a Drug Target
6. Hsp40 Family of Molecular Chaperones
6.1. Hsp70–Hsp40 Partnership as a Drug Target
6.2. Targeting the P. falciparum Hsp70 and Hsp40 Partnership
7. Hsp110 Family of Proteins
7.1. Interaction of Hsp70 with Hsp110
7.2. Targeting the Hsp110–Hsp70 Interaction
8. Conclusions and Future Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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Zininga, T.; Shonhai, A. Small Molecule Inhibitors Targeting the Heat Shock Protein System of Human Obligate Protozoan Parasites. Int. J. Mol. Sci. 2019, 20, 5930. https://doi.org/10.3390/ijms20235930
Zininga T, Shonhai A. Small Molecule Inhibitors Targeting the Heat Shock Protein System of Human Obligate Protozoan Parasites. International Journal of Molecular Sciences. 2019; 20(23):5930. https://doi.org/10.3390/ijms20235930
Chicago/Turabian StyleZininga, Tawanda, and Addmore Shonhai. 2019. "Small Molecule Inhibitors Targeting the Heat Shock Protein System of Human Obligate Protozoan Parasites" International Journal of Molecular Sciences 20, no. 23: 5930. https://doi.org/10.3390/ijms20235930