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Review

Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target?

by
Yuan Dong
1,
Xiaoheng Li
2,
Jinbo Cheng
3,* and
Lin Hou
1,*
1
Department of Biochemistry, Medical College, Qingdao University, Qingdao 266071, China
2
Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China
3
The Brain Science Center, Beijing Institute of Basic Medical Sciences, 100850 Beijing, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(3), 558; https://doi.org/10.3390/ijms20030558
Submission received: 27 December 2018 / Revised: 9 January 2019 / Accepted: 13 January 2019 / Published: 28 January 2019
(This article belongs to the Special Issue Development of Novel Drugs for Alzheimer's Disease and Myasthenia Gravis)
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Abstract

Alzheimer’s disease (AD) is one of the most common causes of dementia. Its pathogenesis is characterized by the aggregation of the amyloid-β (Aβ) protein in senile plaques and the hyperphosphorylated tau protein in neurofibrillary tangles in the brain. Current medications for AD can provide temporary help with the memory symptoms and other cognitive changes of patients, however, they are not able to stop or reverse the progression of AD. New medication discovery and the development of a cure for AD is urgently in need. In this review, we summarized drugs for AD treatments and their recent updates, and discussed the potential of microglia induced neuroinflammation as a target for anti-AD drug development.
Keywords: Alzheimer’s disease; neuroinflammation; microglia; drug development Alzheimer’s disease; neuroinflammation; microglia; drug development

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MDPI and ACS Style

Dong, Y.; Li, X.; Cheng, J.; Hou, L. Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target? Int. J. Mol. Sci. 2019, 20, 558. https://doi.org/10.3390/ijms20030558

AMA Style

Dong Y, Li X, Cheng J, Hou L. Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target? International Journal of Molecular Sciences. 2019; 20(3):558. https://doi.org/10.3390/ijms20030558

Chicago/Turabian Style

Dong, Yuan, Xiaoheng Li, Jinbo Cheng, and Lin Hou. 2019. "Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target?" International Journal of Molecular Sciences 20, no. 3: 558. https://doi.org/10.3390/ijms20030558

APA Style

Dong, Y., Li, X., Cheng, J., & Hou, L. (2019). Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target? International Journal of Molecular Sciences, 20(3), 558. https://doi.org/10.3390/ijms20030558

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