Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation
Abstract
:1. Introduction
2. Results
2.1. CBD Is a Stronger Inhibitor of In Vitro Activated Lymphocyte Proliferation Than THC
2.2. THC and CBD Utilize Different Receptors to Affect Lymphocyte Proliferation
2.3. Cannabinoid Treatment Alters Hematologic Recovery after Bone Marrow Transplantation
2.4. CB2 Receptor Has an Inhibitory Effect on Lymphocyte Recovery
2.5. Cannabis/Cannabinoids Administration for GVHD Prophylaxis
3. Discussion
4. Materials and Methods
4.1. Cannabis Extracts and Cannabinoids
4.2. Inhibitors
4.3. Mice
4.4. Lymphocyte Activation Assays
4.5. RNA Extraction and Real Time PCR Analysis
4.6. Syngeneic BMT Model
4.7. Allogeneic BMT Model
4.8. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Khuja, I.; Yekhtin, Z.; Or, R.; Almogi-Hazan, O. Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation. Int. J. Mol. Sci. 2019, 20, 668. https://doi.org/10.3390/ijms20030668
Khuja I, Yekhtin Z, Or R, Almogi-Hazan O. Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation. International Journal of Molecular Sciences. 2019; 20(3):668. https://doi.org/10.3390/ijms20030668
Chicago/Turabian StyleKhuja, Iman, Zhanna Yekhtin, Reuven Or, and Osnat Almogi-Hazan. 2019. "Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation" International Journal of Molecular Sciences 20, no. 3: 668. https://doi.org/10.3390/ijms20030668