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Peer-Review Record

HBD Inhibits the Development of Colitis-Associated Cancer in Mice via the IL-6R/STAT3 Signaling Pathway

Int. J. Mol. Sci. 2019, 20(5), 1069; https://doi.org/10.3390/ijms20051069
by Song Deng 1, Aiping Wang 1, Xi Chen 1, Qun Du 1, Yanli Wu 1, Gang Chen 2, Wenfeng Guo 1,* and Yanwu Li 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2019, 20(5), 1069; https://doi.org/10.3390/ijms20051069
Submission received: 10 February 2019 / Revised: 21 February 2019 / Accepted: 25 February 2019 / Published: 1 March 2019
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Round 1

Reviewer 1 Report

The revised manuscript has greatly been improved.

Author Response

Dear reviewer:

             Thanks for you suggestion, based on your suggestion, we have modified the introduction to the article to add the following:


Author Response File: Author Response.pdf

Reviewer 2 Report

This version of manuscript have improved significantly as compared to previous one. Here are few more comments which should be taken care by the authors:

In Materials and Methods, please provide the primers sequences of all the genes used in the manuscript. 

What was the company of ECL substrate?

Seigel and Jemal's 2019 publication is available for cancer statistics. Why 2012 is given in the references, please update. 

Please label the Y-axis of figure 4B.

Please mention about the red arrows in Fig. 2B in Figure labels.

Please correct the spacing problem in manuscript. 

Author Response

Dear reviewer:

     Thanks for you advise, based on you suggestion, we made some modifications. 


Author Response File: Author Response.pdf

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