Genes’ Interactions: A Major Contributor to the Malignant Transformation of Endometriosis
Abstract
:1. Introduction
2. Methods
3. Genome Profile of Endometriosis and Associated Cancer
3.1. Genetic Profile of Endometriosis and Endometriosis-Associated Cancers
3.2. Possible Contributors to and Biomarkers of the Malignant Transformation of Endometriosis
4. Discussion
5. Conclusions
Funding
Conflicts of Interest
References
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Novel Mutations | Known Mutations |
---|---|
ARID1A (pLeu2011Gln, pAsn115His, pLeu1309Phe) | PIK3CA, TP53, ARID1A, ARID2, KRAS, LRP1B, PPP2R1A, PTEN, SYNE1, ERBB2, RFX3, MED12, GPC3, MST1R |
ERBB2 (pGly344Cys, pPhe976Leu) | |
GPC3 (pPro273His) | |
LRP1B (pSer2444Pro, pLeu38Phe) | |
MED12 (pLeu1489Val) | |
MST1R (pAla234Thr) | |
PTEN (pArg335Gln) | |
RFX3 (pAla488Thr, pGln97Glu) | |
SYNE1 (pAsn5174Ile, pArg8641Trp, pAsn3630Thr, pPhe3401Leu, pAsp3294Ala, pThr112Ala) |
Key Pathways Mutated | Focal Level Gains of Oncogenic Genes | Focal Level Losses of Oncogenic Genes |
---|---|---|
TP53, PI3K/AKT, MAPK | NTRK1, (33%, 1q chromosome); MYC, (40%, 8q chromosome); GNAS, (47%, 20q chromosome) | TET2, (73%, 4 chromosome); TSC1, (67%, 9q chromosome); BRCA2, (60%, 13q chromosome); SMAD4, (47%, 18q chromosome) |
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Sapalidis, K.; Machairiotis, N.; Zarogoulidis, P.; Vasilakaki, S.; Sardeli, C.; Koimtzis, G.; Pavlidis, E.; Katsaounis, A.; Giannakidis, D.; Michalopoulos, N.; et al. Genes’ Interactions: A Major Contributor to the Malignant Transformation of Endometriosis. Int. J. Mol. Sci. 2019, 20, 1842. https://doi.org/10.3390/ijms20081842
Sapalidis K, Machairiotis N, Zarogoulidis P, Vasilakaki S, Sardeli C, Koimtzis G, Pavlidis E, Katsaounis A, Giannakidis D, Michalopoulos N, et al. Genes’ Interactions: A Major Contributor to the Malignant Transformation of Endometriosis. International Journal of Molecular Sciences. 2019; 20(8):1842. https://doi.org/10.3390/ijms20081842
Chicago/Turabian StyleSapalidis, Konstantinos, Nikolaos Machairiotis, Paul Zarogoulidis, Sofia Vasilakaki, Chrysanthi Sardeli, George Koimtzis, Efstathios Pavlidis, Athanasios Katsaounis, Dimitrios Giannakidis, Nikolaos Michalopoulos, and et al. 2019. "Genes’ Interactions: A Major Contributor to the Malignant Transformation of Endometriosis" International Journal of Molecular Sciences 20, no. 8: 1842. https://doi.org/10.3390/ijms20081842