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Volume 20
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Review

Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity

by
De’Broski R. Herbert
*,
Bonnie Douglas
and
Kelly Zullo
School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2276; https://doi.org/10.3390/ijms20092276
Submission received: 9 April 2019 / Revised: 2 May 2019 / Accepted: 6 May 2019 / Published: 8 May 2019
(This article belongs to the Special Issue Targeting Group 2 Innate Lymphoid Cells (ILC2) in Disease: Central Regulators in Immunity, Tissue Homeostasis, and Physiology)
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Abstract

Group 2 innate lymphoid cells (ILC2) have emerged as a major component of type 2 inflammation in mice and humans. ILC2 secrete large amounts of interleukins 5 and 13, which are largely responsible for host protective immunity against helminth parasites because these cytokines induce profound changes in host physiology that include: goblet cell metaplasia, mucus accumulation, smooth muscle hypercontractility, eosinophil and mast cell recruitment, and alternative macrophage activation (M2). This review covers the initial recognition of ILC2 as a distinct cell lineage, the key studies that established their biological importance, particularly in helminth infection, and the new directions that are likely to be the focus of emerging work that further explores this unique cell population in the context of health and disease.
Keywords: helminth; mucosa; type 2 immunity; innate lymphocyte helminth; mucosa; type 2 immunity; innate lymphocyte
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MDPI and ACS Style

Herbert, D.R.; Douglas, B.; Zullo, K. Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity. Int. J. Mol. Sci. 2019, 20, 2276. https://doi.org/10.3390/ijms20092276

AMA Style

Herbert DR, Douglas B, Zullo K. Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity. International Journal of Molecular Sciences. 2019; 20(9):2276. https://doi.org/10.3390/ijms20092276

Chicago/Turabian Style

Herbert, De’Broski R., Bonnie Douglas, and Kelly Zullo. 2019. "Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity" International Journal of Molecular Sciences 20, no. 9: 2276. https://doi.org/10.3390/ijms20092276

APA Style

Herbert, D. R., Douglas, B., & Zullo, K. (2019). Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity. International Journal of Molecular Sciences, 20(9), 2276. https://doi.org/10.3390/ijms20092276

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