Cell-Based Mechanosensation, Epigenetics, and Non-Coding RNAs in Progression of Cardiac Fibrosis
Abstract
:1. Introduction: Relevance of Cell Mechanics in Cardiac Fibrosis
2. Alterations in Myocardial Compliance and Progression of Cardiac Fibrosis: Epigenetics Aspects
3. Non-Coding RNAs as Mechanotransducers in Cardiac Fibroblast Differentiation and Fibrosis Progression
4. Conclusions
Conflicts of Interest
References
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NcRNA | Target Gene | Pro- or Anti-Fibrotic | References |
---|---|---|---|
miR-18 | CTGF | Anti | [59] |
miR-19 | CTGF | Anti | [59] |
miR-21 | PTEN, SMAD7, STAT3, PPAR-α | Pro | [60] |
miR-29 | COL1A1, 1A2, 4A5, FBN, ELN1, PDGFR, TAB1, ADAM | Anti | [61] |
miR-130a | PPAR-α | Pro | [62] |
miR-133 | CTGF | Anti | [63] |
miR-15 | TGF-β, SMAD7, SMAD3 | Anti | [63] |
miR-30c | CTGF | Anti | [63] |
miR-101 | TGF-β | Anti | [64] |
miR-34 | SMAD4 | Pro | [65] |
miR-212 | FoxO3 | Pro | [66] |
miR-199b | Dyrk1A | Pro | [67] |
miR-150 | PTX3 | Pro | [68] |
miR-155 | SMAD4, SMA2, RhoA | Pro | [69] |
LncRNA-Meg3 | MMP2 | Pro | [70] |
LncRNA-Wisper | Col3α2, Fn1 | Pro | [71] |
LncRNA-Miat | miR-29, miR-30, and miR-133 | Pro | [72] |
LncRNA-Malat1 | TGFBR2, SMAD3 | Pro | [73] |
LncRNA-PRL | miR-Let7d | Pro | [74] |
LncRNA-H19 | DUSP5, ERK1 | Pro | [61] |
LncRNA-n379519 | miR-30 | Pro | [75] |
LncRNA-NR024118 | AT1 | Pro | [76] |
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Ferrari, S.; Pesce, M. Cell-Based Mechanosensation, Epigenetics, and Non-Coding RNAs in Progression of Cardiac Fibrosis. Int. J. Mol. Sci. 2020, 21, 28. https://doi.org/10.3390/ijms21010028
Ferrari S, Pesce M. Cell-Based Mechanosensation, Epigenetics, and Non-Coding RNAs in Progression of Cardiac Fibrosis. International Journal of Molecular Sciences. 2020; 21(1):28. https://doi.org/10.3390/ijms21010028
Chicago/Turabian StyleFerrari, Silvia, and Maurizio Pesce. 2020. "Cell-Based Mechanosensation, Epigenetics, and Non-Coding RNAs in Progression of Cardiac Fibrosis" International Journal of Molecular Sciences 21, no. 1: 28. https://doi.org/10.3390/ijms21010028