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Volume 21
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10.3390/ijms21103666
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Review

A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease

by
Priscilla R. Prestes
†,
Michelle C. Maier
†,
Bradley A. Woods
† and
Fadi J. Charchar
*
School of Health and Life Sciences, Federation University Australia, Ballarat, VIC 3350, Australia
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(10), 3666; https://doi.org/10.3390/ijms21103666
Submission received: 6 April 2020 / Revised: 5 May 2020 / Accepted: 18 May 2020 / Published: 22 May 2020
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in developed countries. CVD encompasses many diseased states, including hypertension, coronary artery disease and atherosclerosis. Studies in animal models and human studies have elucidated the contribution of many genetic factors, including non-coding RNAs. Non-coding RNAs are RNAs not translated into protein, involved in gene expression regulation post-transcriptionally and implicated in CVD. Of these, circular RNAs (circRNAs) and microRNAs are relevant. CircRNAs are created by the back-splicing of pre-messenger RNA and have been underexplored as contributors to CVD. These circRNAs may also act as biomarkers of human disease, as they can be extracted from whole blood, plasma, saliva and seminal fluid. CircRNAs have recently been implicated in various disease processes, including hypertension and other cardiovascular disease. This review article will explore the promising and emerging roles of circRNAs as potential biomarkers and therapeutic targets in CVD, in particular hypertension.
Keywords: long non-coding RNA; circular RNA; microRNA; hypertension; coronary artery disease; atherosclerosis; cardiovascular disease; heart disease long non-coding RNA; circular RNA; microRNA; hypertension; coronary artery disease; atherosclerosis; cardiovascular disease; heart disease

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MDPI and ACS Style

Prestes, P.R.; Maier, M.C.; Woods, B.A.; Charchar, F.J. A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease. Int. J. Mol. Sci. 2020, 21, 3666. https://doi.org/10.3390/ijms21103666

AMA Style

Prestes PR, Maier MC, Woods BA, Charchar FJ. A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease. International Journal of Molecular Sciences. 2020; 21(10):3666. https://doi.org/10.3390/ijms21103666

Chicago/Turabian Style

Prestes, Priscilla R., Michelle C. Maier, Bradley A. Woods, and Fadi J. Charchar. 2020. "A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease" International Journal of Molecular Sciences 21, no. 10: 3666. https://doi.org/10.3390/ijms21103666

APA Style

Prestes, P. R., Maier, M. C., Woods, B. A., & Charchar, F. J. (2020). A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease. International Journal of Molecular Sciences, 21(10), 3666. https://doi.org/10.3390/ijms21103666

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