Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS
Abstract
:1. Introduction
2. Diacylglycerol and Phosphatidic Acid in the Regulation of the Immune Synapse
3. Diacylglycerol Kinase ζ Modulates Diacylglycerol Abundance and Associated Signaling at the Immune Synapse
4. Sorting Nexins in Membrane Trafficking
4.1. SNX-FERM and SNX-BAR Subfamilies
4.2. The SNX27–Retromer Multiprotein Complex Is Involved in Protein Recycling
5. SNX27 in the Regulation of the Immune Synapse
6. SNX27 Interacts with DGKζ and Modulates Diacylglycerol Metabolism at the Immune Synapse
7. Concluding Remarks
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AKT | Protein kinase B |
AP-1 | activator protein 1 |
APC | antigen-presenting cell |
ARF | ADP-ribosylation factor |
ARHG7 | Rho guanine nucleotide exchange factor 7 |
ASCT2 | Alanine, serine, cysteine transporter 2 |
BAR | Bin, amphiphysin, Rvs |
C1 | conserved type 1 PKC domain |
CASP | cytohesin-associated scaffolding protein |
CD28 | Cluster of differentiation 28 |
CENPJ | centromere protein J |
CSC | cargo-selection subcomplex |
CTL | cytotoxic T lymphocyte |
DAG | diacylglycerol |
DGK | diacylglycerol kinase |
EEA1 | early endosome antigen 1 |
ESCRT | endosomal sorting complexes required for transport |
ERK | Extracellular signal-regulated kinase |
FERM | 4.1/ezrin/radixin/moesin |
GLUT1 | glucose transporter 1 |
IP3 | inositol triphosphate |
IS | immune synapse |
LFA-1 | lymphocyte function-associated antigen 1 |
MHC | major histocompatibility complex |
MTOC | microtubule-organizing center |
mTOR | Mammalian target of rapamycin |
Munc | mammalian unc |
NFκB | nuclear factor κB |
NK | natural killer |
N-WASP | neuronal Wiskott–Aldrich syndrome protein |
PA | phosphatidic acid |
PDK1 | Phospholipid-dependent kinase type 1 |
PDZ | postsynaptic density 95/discs large/zonula occludens-1 |
PI | phosphoinositides |
PI3K | phosphatidylinositol 3-kinase |
PIP5K | phosphatidylinositol 4-phosphate 5-kinase |
PIX | p21-activated kinase-interactive exchange factor |
PKC | protein kinase C |
PKD | protein kinase D |
PLC | phospholipase C |
PLD | phospholipase D |
PMA | phorbol-12-myristate-13-acetate |
PtdIns | phosphatidylinositol |
PX | phox homology |
RA | Ras-association |
RasGRP1 | guanyl nucleotide-releasing protein for Ras 1 |
SMAC | supramolecular activation cluster |
SNARE | soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor |
SNX | sorting nexin |
TCR | T-cell receptor |
TGN | trans-Golgi network |
WASH | Wiskott–Aldrich syndrome protein and SCAR homolog |
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González-Mancha, N.; Mérida, I. Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS. Int. J. Mol. Sci. 2020, 21, 4254. https://doi.org/10.3390/ijms21124254
González-Mancha N, Mérida I. Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS. International Journal of Molecular Sciences. 2020; 21(12):4254. https://doi.org/10.3390/ijms21124254
Chicago/Turabian StyleGonzález-Mancha, Natalia, and Isabel Mérida. 2020. "Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS" International Journal of Molecular Sciences 21, no. 12: 4254. https://doi.org/10.3390/ijms21124254