Putative Roles for Peptidylarginine Deiminases in COVID-19
Abstract
:1. Introduction
2. Results
2.1. Summary of PAD Expression in BioProject Data PRJNA631753
PADI 1-6 Isozyme Expression is Differently Regulated in SARS-CoV-2-Infected Tissue
2.2. PADI Expression is Differently Regulated in SARS-CoV-2-Infected Human Bronchial Epithelial Cells (NHBE) and Adenocarcinoma Human Alveolar Basal Epithelial Cells (A549) Cell Lines
2.3. Protein–Protein Interaction Network Identification of Human PAD Isoforms 1–6
3. Discussion
4. Materials and Methods
4.1. In Silico Analysis of BioProject Data for PADI Isozyme mRNA Expression in SARS-CoV-2 Versus Control Lung Tissues
4.2. STRING Protein–Protein Interaction Network Analysis for PAD Isozymes
4.3. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AAV | AAV (antineutrophil cytoplasmic antibody (ANCA))-associated vasculitis |
AD CNS | Alzheimer’s disease Central nervous system |
CoV | Coronavirus |
COVID-19 | Coronavirus disease 2019 |
ETM | Epithelial-mesenchymal transition |
EVs | Extracellular vesicles |
GBS | Guillain-Barre syndrome |
Ig | Immunoglobulin |
KEGG | Kyoto encyclopedia of genes and genomes |
NETosis | Neutrophil extracellular trap formation |
PAD | Peptidylarginine deiminase |
PD | Parkinson’s disease |
RA | Rheumatoid arthritis |
SARS | Severe acute respiratory syndrome |
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Arisan, E.D.; Uysal-Onganer, P.; Lange, S. Putative Roles for Peptidylarginine Deiminases in COVID-19. Int. J. Mol. Sci. 2020, 21, 4662. https://doi.org/10.3390/ijms21134662
Arisan ED, Uysal-Onganer P, Lange S. Putative Roles for Peptidylarginine Deiminases in COVID-19. International Journal of Molecular Sciences. 2020; 21(13):4662. https://doi.org/10.3390/ijms21134662
Chicago/Turabian StyleArisan, Elif Damla, Pinar Uysal-Onganer, and Sigrun Lange. 2020. "Putative Roles for Peptidylarginine Deiminases in COVID-19" International Journal of Molecular Sciences 21, no. 13: 4662. https://doi.org/10.3390/ijms21134662