Metabolomic Insight into Polycystic Ovary Syndrome—An Overview

Rajska, Anna; Buszewska-Forajta, Magdalena; Rachoń, Dominik; Markuszewski, Michał Jan

doi:10.3390/ijms21144853

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Metabolomic Insight into Polycystic Ovary Syndrome—An Overview

¹

Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Hallera 107, 80-416 Gdańsk, Poland

²

Department of Clinical and Experimental Endocrinology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2020, 21(14), 4853; https://doi.org/10.3390/ijms21144853

Submission received: 20 May 2020 / Revised: 4 July 2020 / Accepted: 7 July 2020 / Published: 9 July 2020

(This article belongs to the Special Issue Novel Physiology and Molecular Pathology of Reproduction, Novel Treatments of Infertility)

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Abstract

Searching for the mechanisms of the polycystic ovary syndrome (PCOS) pathophysiology has become a crucial aspect of research performed in the last decades. However, the pathogenesis of this complex and heterogeneous endocrinopathy remains unknown. Thus, there is a need to investigate the metabolic pathways, which could be involved in the pathophysiology of PCOS and to find the metabolic markers of this disorder. The application of metabolomics gives a promising insight into the research on PCOS. It is a valuable and rapidly expanding tool, enabling the discovery of novel metabolites, which may be the potential biomarkers of several metabolic and endocrine disorders. The utilization of this approach could also improve the process of diagnosis and therefore, make treatment more effective. This review article aims to summarize actual and meaningful metabolomic studies in PCOS and point to the potential biomarkers detected in serum, urine, and follicular fluid of the affected women.

Keywords: metabolomics; polycystic ovary syndrome (PCOS); metabolites; biomarkers; mass spectrometry

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MDPI and ACS Style

Rajska, A.; Buszewska-Forajta, M.; Rachoń, D.; Markuszewski, M.J. Metabolomic Insight into Polycystic Ovary Syndrome—An Overview. Int. J. Mol. Sci. 2020, 21, 4853. https://doi.org/10.3390/ijms21144853

AMA Style

Rajska A, Buszewska-Forajta M, Rachoń D, Markuszewski MJ. Metabolomic Insight into Polycystic Ovary Syndrome—An Overview. International Journal of Molecular Sciences. 2020; 21(14):4853. https://doi.org/10.3390/ijms21144853

Chicago/Turabian Style

Rajska, Anna, Magdalena Buszewska-Forajta, Dominik Rachoń, and Michał Jan Markuszewski. 2020. "Metabolomic Insight into Polycystic Ovary Syndrome—An Overview" International Journal of Molecular Sciences 21, no. 14: 4853. https://doi.org/10.3390/ijms21144853

APA Style

Rajska, A., Buszewska-Forajta, M., Rachoń, D., & Markuszewski, M. J. (2020). Metabolomic Insight into Polycystic Ovary Syndrome—An Overview. International Journal of Molecular Sciences, 21(14), 4853. https://doi.org/10.3390/ijms21144853

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Metabolomic Insight into Polycystic Ovary Syndrome—An Overview

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